Petechiae In Children (PIC) Study: Defining A Clinical Decision Rule for The Management Of Fever and Non-Blanching Rashes In Children Including The Role Of Point Of Care Testing For Procalcitonin & Neisseria Meningitidis DNA.

Conditions

Meningitis, Meningitis, Meningococcal, Meningococcal Disease, Meningococcal Infections, Meningococcal Sepsis, Sepsis

Keywords

meningococcal, neisseria meningitidis, sepsis, meningitis, procalcitonin, PCT, LAMP, loop-mediated-isothermal AMPlification

Brief summary

A fever and a non-blanching rash is a relatively common reason for a child to attend an emergency department. A fever and a non-blanching rash can be an early sign of a life-threatening infection known as meningococcal disease. The aim of the PIC study is to determine how best to diagnose early meningococcal disease in children. In particular the investigators are interested in researching how quick bedside tests can be used to do this.

Detailed description

A fever an a non-blanching rash is a relatively common presentation the the emergency department. A minority of children with a fever and a non-blanching rash with have a life-threatening infection. Currently it is very difficult to determine those children that require urgent treatment from those that have a simple viral illness. The aim of the PIC study is to research how to better diagnose those serious infections earlier. Data from the study will be used to test the effectiveness of current practice and to identify areas where current practice could be improved.

Waterfield T, Maney JA, Fairley D, Lyttle MD, McKenna JP, Roland D, Corr M, McFetridge L, Mitchell H, Woolfall K, Lynn F, Patenall B, Shields MD, Paediatric Emergency Research in the UK and Ireland (PERUKI) Group.

2020-11-1015 citations

10.1016/s1473-3099(20)30474-6

Diagnostic test accuracy of point-of-care procalcitonin to diagnose serious bacterial infections in children.

Waterfield T, Maney JA, Lyttle MD, McKenna JP, Roland D, Corr M, Patenall B, Shields MD, Woolfall K, Fairley D, Paediatric Emergency Research in the UK and Ireland (PERUKI).

2020-10-215 citations

10.1186/s12887-020-02385-2

Loop-mediated isothermal amplification for the early diagnosis of invasive meningococcal disease in children

Thomas Waterfield, Mark D Lyttle, James McKenna, Julie-Ann Maney, Damian Roland et al. (10 authors)

Archives of Disease in Childhood2020-06-25

10.1136/archdischild-2020-319139

Parents’ and clinicians’ views on conducting paediatric diagnostic test accuracy studies without prior informed consent: qualitative insight from the Petechiae in Children study (PiC)

Thomas Waterfield, Mark D Lyttle, Michael D. Shields, Derek Fairley, Damian Roland et al. (7 authors)

Archives of Disease in Childhood2019-06-0710 citations

10.1136/archdischild-2019-317117

The “Petechiae in children” (PiC) study: evaluating potential clinical decision rules for the management of feverish children with non-blanching rashes, including the role of point of care testing for Procalcitonin & Neisseria meningitidis DNA – a study protocol

Thomas Waterfield, Mark D Lyttle, Derek Fairley, James McKenna, Kerry Woolfall et al. (10 authors)

BMC Pediatrics2018-07-3010 citations

10.1186/s12887-018-1220-x

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 18 Years

Healthy volunteers

No

Inclusion criteria

* Fever (recorded or reported) 38 degrees Centigrade or higher and a non-blanching rash (at the time of presentation) * Features of meningococcal sepsis/meningitis

Exclusion criteria

* Known haematological conditions such as haematological malignancy, idiopathic thrombocytopenic purpura and coagulopathy

Design outcomes

Primary

Measure	Time frame	Description
Confirmation of meningococcal infection	72 hours from testing	Blood and Cerebrospinal fluid (CSF) culture or quantitative Polymerase Chain Reaction (PCR) will be used to confirm meningococcal infection

Countries

United Kingdom

Outcome results