Bronchopulmonary Dysplasia
Conditions
Brief summary
Very preterm infants are at high risk to develop to bronchopulmonary dysplasia (BPD) for the lack of effective measures to prevent or ameliorate this common and serious disorder. BPD remains a major cause of mortality and lifelong morbidity in preterm infants
Detailed description
Several studies have shown that transplantation of mesenchymal stem cells (MSCs) in immunocompetent animals attenuates lung injury, such as impaired alveolarization, inflammatory response, increased apoptosis, and fibrosis. Human umbilical cord blood (hUCB) is considered a better source of MSCs because of their ready availability and greater proliferative capacity and less antigenicity than other cell types. transplantation of hUCB-derived MSCs should be effective in treating BPD. The safety and efficacy of MSC transplantation for prevention of BPD has not been tested previously, however.
Interventions
allogeneic human umbilical cord blood (hUCB)-derived mesenchymal stem cell (MSC) transplantation will be given to preterm infants
MSC transplantation will be not given to preterm infants
Sponsors
Children's Hospital of Chongqing Medical University
Chongqing Maternal and Child Health Hospital
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Months to 3 Months
Healthy volunteers
No
Inclusion criteria
* diagnosed with BPD
Exclusion criteria
* parents' rejection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| death | within two years | the infant is dead due to lung disease |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Bayley Scales of Infant Development | 30 months after birth | scores of Bayley Scales of Infant Development at 2 months old and 2 years old |
Countries
China
Outcome results
None listed