Contamination of Bacillus Species Sepsis.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03377530

Acronym

BACILLUS

Enrollment

Registered

2017-12-19

Start date

2008-01-01

Completion date

2016-08-31

Last updated

2026-06-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bacillus Cereus Infection

Keywords

Bacillus Cereus, Premature neonates

Brief summary

Bacillus species are ubiquitous gram-positive spore-forming organisms. They rarely cause disease in the immunocompetent and are more frequently isolated as a culture contaminant. However, Bacillus Species can cause severe systemic infections in immunocompromised patients including preterm infants. The purpose of this study is to identify the risk factors of these infections.

Detailed description

Non-anthrax Bacillus Species bacteria can be responsible for food poisoning and local infections. Rarely, they lead to severe infections like blood stream infections and meningitis especially in immunocompromised patients like preterm infants. Bacillus Cereus is the most common members of the genus Bacillus. Only few reports studied these systemic infections in premature neonates. In order to identify the risk factors for severe Bacillus Species infections, we studied retrospectively eleven cases of these infections in our NICU and reviewed series and report cases in literature.

Interventions

DIAGNOSTIC_TESTWays to prevent these infections.

The purpose of this database is to describe the pathogenicity of this germ, the incriminated modes of contamination. The collaborators studied the factors of poor prognosis and propose ways to prevent these infections.

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 28 Days

Inclusion criteria

* cases of Bacillus Species sepsis * cases of Bacillus species meningitis * with significant change in clinical status * Bacillus Species is the only organism isolated

Exclusion criteria

* Bacillus Species isolated with other organisms and Bacillus Species without clinical change were considered to be contaminants

Design outcomes

Primary

Measure	Time frame	Description
Severe infection rate due to Bacillus Sp germ	Through study completion, an average of 1 year.	The purpose of this database is to mesure the pathogenicity of this germ based on the severe infection rate

Secondary

Measure	Time frame	Description
To collecte the incriminated modes of contamination.	Through study completion, an average of 1 year.	The purpose of this database is to describe the incriminated modes of contamination.

Countries

France

Contacts

PRINCIPAL_INVESTIGATORMohamed Amine YANGUI

Hôpital NOVO

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 10, 2026