Androgenetic Alopecia
Conditions
Brief summary
Platelet rich plasma (PRP) is an autologous preparation of human plasma with high concentration of platelets. Platelets release numerous growth factors, which stimulate cell proliferation and differentiation. The purpose of this research is to investigate the potential of PRP injection for treatment of hair loss. Clinical outcomes will be assessed by noninvasive techniques including dermoscopy, multiphoton microscopy, optical coherence tomography, optical Doppler tomography and multispectral imaging.
Interventions
PROCEDUREPlatelet rich plasma
Blood drawn from each participant will be spun down to separate platelets. Platelets will be injected into that patient's scalp.
Sponsors
University of California, Irvine
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 95 Years
Healthy volunteers
Yes
Inclusion criteria
* Over 18 years of age * Ability to understand and carry out instructions * Diagnosed with alopecia
Exclusion criteria
* Inability to understand and.or carry out instructions * Pregnant women * Use of any topical medication (such as minoxidil or any other solution for hair growth), oral medication (finasteride, dutasteride, or antiandrogens), laser therapy, or chemotherapy, within the preceding 4 weeks. * Personal medical history of bleeding disorders * Personal medical history of platelet dysfunction syndrome * Anti-coagulation therapy or nonsteroidal anti-inflammatory drugs in the last 1 week.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hair density to measure the efficacy of treatment | 6 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Terminal hair density | 6 months | — |
| Anagen hair percentage | 6 months | — |
| Hair count (number of hairs/0.65 cm2) | 6 months | — |
| Anagen/telogen ratio | After 3 and 6 months | — |
| Changes in hair structure, diameter, and blood flow | 6 months | As measured by optical coherence tomography |
| Telogen hair percentage | 6 months | — |
Countries
United States
Outcome results
None listed