Effects of Mixed Nut Consumption on Satiety and Weight Management

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03375866

Enrollment

Registered

2017-12-18

Start date

2016-12-01

Completion date

2028-12-01

Last updated

2026-01-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Satiety

Brief summary

The first goal of the proposed study is to determine acute and long-term effects of mixed nuts (almonds, hazelnuts, pecans, pistachios, walnuts, and peanuts) on metabolic parameters and weight management. While numerous studies have shown the beneficial effects of nuts on promoting negative energy balance and weight loss, mechanistic studies exploring how the inclusion of nuts in the diet promotes a negative energy balance and weight loss have not been conducted. The second goal is to determine the mechanisms by which mixed nut consumption regulates of food intake and body weight.

Interventions

OTHERPretzels

Subjects consume 240 kcal of pretzels daily for 16 weeks.

OTHERMixed nuts

Subjects consume 240 kcal of mixed nuts daily for 16 weeks.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

* 18-55 years old * BMI 27-40

Exclusion criteria

* Smoker * Pregnant woman * Required dietary supplement use * Required medication of metabolic disorders * Allergy to nuts or gluten

Design outcomes

Primary

Measure	Time frame	Description
Change of Satiety	0, 20, 40, 60, 90 and 120 minutes post snack consumption	Hunger feeling (appetite) will be examined using visual analog scale (0-10): 0 least and 10 greatest
Change of glucose level	Baseline, 40 minutes post snack consumption, and 8 weeks and 16 weeks post daily consumption	Glucose level will be examined using glucose analysis
Change of insulin level	Baseline, 40 minutes post snack consumption, and 8 weeks and 16 weeks post daily consumption	Insulin level will be examined using an ELISA biochemical method
Change of cholesterol levels	8 weeks and 16 weeks post daily consumption	Cholesterol levels will be examined using a biochemical method
Change of Lp(a)	8 weeks and 16 weeks post daily consumption	Lp(a) levels will be examined using an ELISA biochemical method

Secondary

Measure	Time frame	Description
Change of microbiome	8 weeks and 16 weeks post daily consumption	Diversity of microbiome will be analyzed in fecal samples

Countries

United States

Contacts

CONTACTMee Young Hong

mhong2@mail.sdsu.edu619-594-2392

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 9, 2026