Oral Contraceptive and Strength Training

E5 - Oral Contraceptive and Strength Training (2nd Generation)

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03374878

Enrollment

Registered

2017-12-15

Start date

2018-02-01

Completion date

2019-01-01

Last updated

2019-09-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

exercise, oral contraceptive, strength training

Brief summary

Cross sectional study investigating the effect of strength training in users and non-users of oral contraceptives (OC) (2nd generation OC)

Interventions

OTHERno oral contraceptive and training

10 weeks of training in a group of oral contraceptive users

OTHERoral contraceptive and training

10 weeks of training in a group of users of oral contraceptives

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Intervention model description

Cross sectional study with 16 in each group.

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* 18.5 - 30 years * BMI \< 30

Exclusion criteria

* Medicine influencing protein turnover * Surgery on the knee * Arthritis * Diabetes * Smoking * irregular menstruation (\<24 days or \>35 days cycles) * Non-users: not have used contraceptives for the last 3 months. * Unstable weight (+/- 5 kg within the last 6 months) * Regular training/exercise more than 2 hours/week for the last 6 months. Maximum 70 km of cycling transport/week. * Strength training \>1time/month for the last 6 months. * Pregnancy * Diet og eating disorder * Can not read or understand danish

Design outcomes

Primary

Measure	Time frame	Description
Muscle mass	Baseline + after 10 weeks of resistance training.	Change in muscle mass determined by MRI scan of thigh muscle

Secondary

Measure	Time frame	Description
Muscle fiber size	Baseline + after 10 weeks of resistance training.	Change in muscle fiber cross sectional area measured by histology.
Muscle strength	Baseline + after 10 weeks of resistance training.	Change in isometric strength
Blood values	Baseline + after 10 weeks of resistance training.	Change in sex hormone profile measured by blood sample analysis
Functionality	Baseline + after 10 weeks of resistance training.	Change in jump performance by RSI (Reactive strength index) measures
Fat free mass (FFM)	Baseline + after 10 weeks of resistance training.	Change in FFM measured by dual energy x-ray absorptiometry (DXA) scan of whole body composition

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026