co2 Gap and co2/o2 Ratio in Liver Transplant Patients

Use of the Venoarterial Carbon Dioxide Gap and Arteriovenous Oxygen Content to Guide the Resuscitation in the Liver Transplant Patients

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03374579

Acronym

co2gap

Enrollment

Registered

2017-12-15

Start date

2017-06-12

Completion date

2018-09-12

Last updated

2018-03-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Transplantation

Brief summary

finding surrogate to co to trace the effect of preload challenge would make the test more applicable without the need of advanced hemodynamic monitors,suggested that co2 gap can be used to detect FR after mini fluid challenge and fluid bolts .

Detailed description

use of carbon dioxide gap and arterio venous oxygen content to trace the effect of preload challenge by giving via a specific venous line , first 150 ml is infused over one minute, after stroke volume at one minute measure the remaining 350 ml is infused over 14 minutes at constant rate , the fluid challenge performed with albumin 5% , fluid responsiveness is an increase in stroke volume by 15% after infusion of 500ml albumin 5%. Objectives is to investigate the ability of VA-co2 gap and gap/ ratio to predict the hemodynamic response to mini fluid challenge, and to compare the validity of VA-co2 gap and gap/ratio with svo2 for prediction of fluid responsiveness.

Interventions

DIAGNOSTIC_TESTFluid challenge

Fluid challenge and measure change in co2 gap

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Intervention model description

Fluid challenge with assessment of change of co2 gap

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* patients post liver transplantation * serum lactate \>2mmol/L

Exclusion criteria

* age less than 18 years * patients with fulminant liver failure.

Design outcomes

Primary

Measure	Time frame	Description
co2gap	30 minuets after fluid bolus	Difference between arterial and venous co2 gap

Secondary

Measure	Time frame	Description
Stroke volume	Baseline 30 minutes after Icu admission, 1 minutes after mini fluid challenge , 30 minutes after fluid bolus	Stroke volume assessed by cardiometry

Countries

Egypt

Contacts

Primary ContactAhmed m Mukhtar, Professor

Ahmed.mukhtar@kasralainy.edu.eg+0220111420844

Backup ContactHassan kh Nagi, Professor

hknagi@hotmail.com01223634792

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026