Nasal Polyps, Sinusitis
Conditions
Keywords
Chronic rhinosinusitis, Eosinophil, Surgery, Diagnosis
Brief summary
Previous studies have demonstrated that the eosinophilic inflammation of nasal mucosa is associated with the uncontrolled condition of chronic rhinosinusitis after surgery. However, the definition of the eosinophilic chronic rhinosinusitis is not very clear. Japanese researchers have designed a scoring system to diagnose eosinophilic chronic rhinosinusitis. In this study, the investigators hope to examine the practicability of this scoring system and have a better knowledge of eosinophilic chronic rhinosinusitis in china.The retrospective study was conducted in a tertiary hospital. Participants received functional endoscopic sinus surgery more than 1 years were called back for evaluation. A diagnosis cut off value of eosinophil count was determined by the surgery prognosis. Then different factors were compared between participants with eosinophilic CRS and those with non-eosinophilic CRS to establish the appropriated diagnosis approach for eosinophilic CRS.
Detailed description
The retrospective study was conducted in a tertiary hospital. Participants received functional endoscopic sinus surgery more than 1 years were called back for evaluation. A diagnosis cut off value of eosinophil count was determined by the surgery prognosis. Then different factors were compared between participants with eosinophilic CRS and those with non-eosinophilic CRS to establish the appropriated diagnosis approach for eosinophilic CRS.
Interventions
DIAGNOSTIC_TESTsinonasal outcome test-22
Evaluate the nasal mucosal inflammation condition and overall quality-of-life of CRS patients
Sponsors
Jianbo Shi
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of chronic rhinosinusitis according to European position paper of rhinosinusitis and nasal polyps 2007.
Exclusion criteria
* Immunodeficiency diseases, history of head and/or facial trauma, cancer or organ transplant recipients. * Pregnancy or lactation. * Acute respiratory tract infection within one month before the study. * Patients without pathological samples. * Antrochoanal polyp and cyst of the paranasal sinuses.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| nasal symptoms | through study completion, an average of 2 year | presence of bothersome congestion or rhinorrhea or olfactory loss or headache.(VAS more than 7 points). |
| endoscopic appearance indicate the uncontrol of CRS | through study completion, an average of 2 year | The presence of diseased mucosa (nasal polyps, mucopurulent secretions,and/or inflamed mucosa) under endoscopy. (Lund-kennedy endoscopic score: Polyp≥1 or Oedema≥2 or Discharge≥2; 0-Absence of polyps;1-polyps in middle meatus only;2-polyps beyond middle meatus but not blocking the nose completely;3-polyps completely obstructing the nose. Oedema: 0-absent; 1-mild; 2-severe.Discharge: 0-no discharge; 1-clear, thin discharge; 2-thick, purulent discharge.) |
Countries
China
Contacts
Primary ContactJianbo Shi, doctor
Outcome results
None listed