Perfusion and Hypoxia
Conditions
Keywords
FDG, perfusion, hypoxia, tumor, PET
Brief summary
Investigators want to use 18F-FDG PET/CT imaging to reflect tumor perfusion and hypoxia.
Detailed description
Perfusion and hypoxia were independent prognositic parameters for tumor patients. Developing a method that can evaluate tumor perfusion and hypoxia noninvasively and conveniently was in urgent need. 18F-FDG PET/CT imaging could reflect tumor hypoxia in 60min balanced imaging was proved and accepted. Moreover, FDG could diffuse out of the vasculature and through cell membranes passively and rapidly due to its lipophilicity, its regional uptake at initial times is expected to reflect tumor perfusion. So, investigators want to use 18F-FDG PET/CT imaging to evaluate tumor perfusion and hypoxia simutaniously，in order to guide the clinical diagnosis and treatment.
Interventions
DIAGNOSTIC_TEST18F-FDG PET/CT initial-time imaging
18F-FDG intravenous bolus injection after a fasting perid of more than 6 hours, simultaneously,PET/CT imaging using one bed lasting 5 minutes was underwent.
DIAGNOSTIC_TEST18F-FDG PET/CT balanced-time imaging
18F-FDG intravenous injection after a fasting perid of more than 6 hours. After 60 minutes, PET/CT imaging using 6-7 bed positions each lasting 2 minutes was underwent.
Sponsors
Harbin Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* 1.solid tumor proved by pathology(d\>3.0cm); * 2.age\>18-year-old; * 3\. Karnofsky performance status \>70; * 4.sign the informed consent.
Exclusion criteria
* 1.There are obvious metal implants near the tumor; * 2.Can not lie still for 15 minutes. * 3.Pregnancy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation of the distribution of FDG between initial-time and balanced-time PET/CT | 2018.1 | Initial-time and balanced-time PET/CT imaging were registrated using PET/CT Compare software in GE AW4.6 workstation. FDG distribution was evaluated in each imaging and the correlation was evaluated. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| SUVs in initial-time and balanced-time PET/CT | 2018.1 | the SUVmax and SUVmean was calculated in well-perfused area and hypoxia area in tumors using PET/CT Render software in GE AW4.6 workstation. |
Countries
China
Contacts
Primary ContactYingying Sun, Dr
Outcome results
None listed