Gastric Cancer, Postoperative Complications
Conditions
Keywords
Distal Gastrectomy, Postoperative Reflux Rate, Gastric Cance, Laparoscopic Surgery
Brief summary
Postoperative gastroesophageal reflux is one of the most common complications of distal gastrectomy. With more attention paid on it by surgeons, several new operation methods have been practised. Among all these, distal gastrctomy with Billroth II + Braun anastomosis was reported to be an useful method to decrease postoperative reflux rate. Meanwhile, the direction of anastomotic peristalsis has also been reported to affect the anastomosis and thus make difference in reflux rate. We design this study to investigate the potential effect and the superiority of antiperistaltic vs isoperistaltic Billroth II + Braun reconstruction in distal gastrectomy.
Interventions
PROCEDUREIsoperistaltic Billroth II + Braun anastomosis
Laparoscopic distal gestrectomy will be applied with Isoperistaltic Billroth II + Braun reconstruction
PROCEDUREAntiperistaltic Billroth II + Braun anastomosis
Laparoscopic distal gestrectomy will be applied with antiperistaltic Billroth II + Braun reconstruction
Sponsors
Shanghai Minimally Invasive Surgery Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Pathologically diagnosed as gastric cancer before surgery * Clinical staging: cT1-4aN0-3M0 * Postoperative evaluation concluded B-II B anastomosis * Consent assigned
Exclusion criteria
* Diagnosed with other malignancies within 2 years * Gastric cancer with clinical staging: cT4b or M1 * Women with pregnancy or breast-feeding * Emergency procedures * Consent not assigned
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative Reflux Rate | 1 yrs | The rate of bile reflux within 1yrs postoperation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Disease-free survival | 3yrs | 3yrs DFS |
| Overall survival | 3 yrs | 3yrs OS |
| Surgery-related reflux gastritis rate | 1yrs | The rate of surgery-related reflux gastritis rate |
| Surgery-related reflux esophagitis rate | 1 yrs | The rate of surgery-related reflux esophagitis rate |
Contacts
Primary ContactMinhua Zheng, M.D. PhD.
Backup ContactJing Sun, M.D. PhD.
Outcome results
None listed