coMparison Between invAsive and Non-invasive assessmenT on Blood Pressure and Cardiac Function in HealthY Participants

coMparison Between invAsive and Non-invasive assessmenT on Blood Pressure and Cardiac Function in HealthY Participants: the MATCHY Study

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03372616

Acronym

MATCHY

Enrollment

100

Registered

2017-12-13

Start date

2018-01-31

Completion date

2018-06-30

Last updated

2017-12-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Volunteer

Keywords

aortic blood pressure, diastolic dysfuntion, echocardiography, left ventricular ejection fraction

Brief summary

This is a cross-sectional cohort study which aims to compare the invasive and non-invasive assessments on aortic blood pressure and cardiac funtion in subjects without history of cardio-vascular disease. Left ventricular (LV) filling pressure, LV volume, and aortic blood pressure will be measured invasively. Non-invasive assessment includes echocardiography,aortic, and carotid blood pressure measurement.

Interventions

DIAGNOSTIC_TESTInvasive left ventricular diastolic function assessment

Left ventricular (LV) polyethylene catheter was inserted into left ventricular to directly measure LV filling pressure.

DIAGNOSTIC_TESTInvasive aortic blood pressure measurement

Aortic blood pressure will be measured with polyethylene catheter in aortic root.

DIAGNOSTIC_TESTNon-Invasive left ventricular diastolic function assessment

Echocardiography will be performed in all participants to assess left ventricular diastolic function non-invasively.

DIAGNOSTIC_TESTNon-Invasive aortic blood pressure measurement

Three devices (Sphygmocor \[AtCor Medical, Australia\], PulsePen \[DiaTecne SRL, Italy\], and Mobil-O-Graph \[IEM, Germany\] ) will be used to assess aortic blood pressure non-invasively when participants are undergoing invasive aortic blood pressure measurement.

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Over or equal to 18 years old; * Agree to participate the study and sign informed written consent; * Any change of drugs which effect the hemodynamics during 1 month prior to enrollment; * Proposed to perform coronary angiography and left left ventriculography in hospital;

Exclusion criteria

* Non-sinus rhythm or frequent extra systoles; * Identified coronary artery disease via coronary angiography; * Diagnosed pulmonary vascular or parenchymal disease; * Hypertrophic cardiomyopathy, restrictive cardiomyopathy, or constrictive pericarditis; * Stenosis or insufficiency of valves (moderate and above); * Heart transplant; * Congenital heart disease; * Inadequate imaging or doppler parameter quality in echocardiography.

Design outcomes

Primary

Measure	Time frame	Description
Left ventricular filling pressure assessment with left heart catheterization	1 day	All participants will receive invasive left ventricular filling pressure assessment with left heart catheterization.
Left ventricular diastolic function assessment with echocardiography using ASE recommendations	1 day	All participants will receive non-invasive left ventricular diastolic function assessment with echocardiography. The ASE-recommended (American Society of Echocardiography) creteria would be used to define left ventricular diastolic dysfunction.
Left ventricular diastolic function assessment with echocardiography using EACVI recommendations	1 day	All participants will receive non-invasive left ventricular diastolic function assessment with echocardiography. The EACVI-recommended (European Association of Cardiovascular Imaging) creteria would be used to define left ventricular diastolic dysfunction.

Secondary

Measure	Time frame	Description
Aortic blood presure obtained with Sphygmocor device	1 day	Sphygmocor device (AtCor Medical, Australia) will be used in non-invasive aortic blood presure measurement with standard protocols shown in its user manual.
Aortic blood presure obtained with catheterization	1 day	Catheterization will be used in invasive aortic blood presure measurement. The cather will be placed in the aortic root while measuring the blood pressure.
Aortic blood presure obtained with PulsePen device	1 day	PulsePen device (DiaTecne SRL, Italy) will be used in non-invasive aortic blood presure measurement with standard protocols shown in its user manual.
Aortic blood presure obtained with Mobil-O-Graph device	1 day	Mobil-O-Graph (IEM, Germany) device will be used in non-invasive aortic blood presure measurement with standard protocols shown in its user manual.

Contacts

Primary ContactChen Chi, M.D.

chichen.david@gmail.com086-150-2178-7802

Backup ContactYi Zhang, M.D., Ph.D.

yizshcn@gmail.com086-189-1768-6332

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026