Bruxism, Myalgia, PRP, Temporomandibular Disorder
Conditions
Brief summary
The Platelet-Rich Plasma intramuscular injections into the masseter and temporalis muscle were performed to reduce painful temporomandibular disorder symptoms,such as myalgia, myofascial pain and myofascial pain with referrals. Patients(n=120) were randomly divided into two groups: experimental(n=60) and control group(n=60). In controls injections with 0,9% NaCl were performed. Pain intensity was measured with NPRS (numeriic pain rating scale, 0= no pain, 11= the worst pain that one can imagine) before(0 day), during(10 day) and after(20 day) the therapy with PRP injections.
Detailed description
Patients(n=120) attending The Department of Temporomandibular Disorders and Orthodontics at the Silesian Medical University Poland, Zabrze were enrolled to the study and randomly divided into one of two groups: experimental and control group. Platelet-Rich Plasma(PRP) was prepared for each patient and an intramuscular injections of 0,5 ml PRP into 6 points at each side were performed in experimental group. A follow-up appointment was made after 10 and 20 days and in each visit an injection of PRP or 0,9% NaCl was performed. Pain intensity was measured in NPRS(numeric pain rating scale) and collected data data were analyzed.
Interventions
BIOLOGICALPlatelet-Rich Plasma intramuscular injections
A platelet-rich plasma intramuscular injections into the trigger points of painful muscles were performed.
BIOLOGICALPlacebo Comparator: 0,9% NaCl intramuscular injections
A 0,9% NaCl intramuscular injections into the trigger points of painful muscles were performed.
Sponsors
Medical University of Silesia
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Masking description
double blinded study
Intervention model description
An intervention performed in experimental group and control group
Eligibility
Sex/Gender
ALL
Age
23 Years to 42 Years
Healthy volunteers
Yes
Inclusion criteria
1. presence of local myalgia, myofascial pain and myofascial pain with referral within masseter muscles according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) (II.1.A. 1, 2 and 3) 2. patient's agreement for taking part into the research study
Exclusion criteria
1. patients being treated with or addicted to analgesic drugs and/or drugs that affect muscle function 2. presence of contraindications for injection therapy 3. patients being treated by neurologist for neurological disorders and/or neuropathic pain and/or headache 4. patients after traumas to the head and neck region in the previous 2 years 5. edentulous patients 6. patients after radiotherapy 7. presence of severe mental disorders 8. pregnancy or lactation 9. pain of dental origin 10. presence of malignancy 11. drug and/or alcohol addiction 12. patients with needle phobia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain intensity reduction in VAS scale,(VAS scale 0-10 points) | 14 days | Decrease in pain intensity in masseter and temporalis muscles. |
Countries
Poland
Outcome results
None listed