Alcohol Drinking
Conditions
Brief summary
This study examines the effects of moderate alcohol intake on the brain, the immune system, and cognition.
Detailed description
The study involves a within-subjects, pre/post design to assess the effects of a moderate dose of alcohol on immune biomarkers, neurobiological measures, and cognitive functioning. The study recruits healthy adults (ages 21-45) from the community to complete the experimental protocol. Participants complete magnetic resonance imaging scans, blood sample collection, and cognitive testing in the context of alcohol consumption.
Interventions
DRUGEthanol
Moderate alcohol consumption
Sponsors
National Institute of General Medical Sciences (NIGMS)
Brown University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
21 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Ages 21-45 years * Able to speak and read English at least at 8th grade level * Moderate self-reported alcohol use in the past year * Body mass index in normal to overweight range * Right-handed
Exclusion criteria
* History of heavy drinking * Currently seeking alcohol or drug treatment * Chronic disease requiring use of medication * Recent antibiotic or probiotic use * Chronic daily use of NSAIDs * Chronic GI disorder * Use of illicit drugs * Major psychiatric disorder or suicidality * Fainting, weakness, infection, excessive bruising, or distress resulting from standard blood draw * Safety contraindication for MRI scan * Inability to abstain from use of tobacco products prior to or during study * Inability to abstain from use of cannabis prior to or during study * Pregnant, nursing, or may become pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Immune biomarkers | 1-3 hours after alcohol intake |
Countries
United States
Outcome results
None listed