Hypertension
Conditions
Keywords
hypertension
Brief summary
To compare the urinary metabolomes on individuals undergone three different healthy diets--a carbohydrate-rich diet, a protein-rich diet, or a diet rich in unsaturated fat.
Detailed description
BACKGROUND: This study based on the OmniHeart dietary intervention study, a randomized, three period cross-over feeding study that compared the effects on blood pressure and plasma lipids of three DASH-like diets: a carbohydrate-rich (CARB) diet pattern, a rich in protein (PROT) and a rich in unsaturated (MUFA) fat, predominantly monounsaturated fat diet (see full details of OmniHeart dietary intervention https://clinicaltrials.gov/ct2/show/record/NCT00051350). This metabonomic study aims to evaluate the feasibility of identifying individuals showing variation in clinical response to three different healthy diets, with the purpose of reducing cardiovascular disease (CVD) risk, using proton nuclear magnetic resonance (NMR) based metabolic phenotyping approach.
Interventions
OTHERCARB rich diet
Consumed CARB rich diet for 6 weeks with a washout period of at least 2 weeks before the next intervention
OTHERMUFA rich diet
Consumed MUFA rich diet for 6 weeks with a washout period of at least 2 weeks before the next intervention
OTHERPROT rich diet
Consumed PROT rich diet for 6 weeks with a washout period of at least 2 weeks before the next intervention
Sponsors
University of Kent
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* with pre-hypertension (systolic BP of 120 to 139 mmHg and/or diastolic BP of 80 to 89 mmHg) or stage 1 hypertension (systolic BP of 140 to 159 mm Hg and/or diastolic BP of 90 to 99 mm Hg) and without diabetes or prior CVD
Exclusion criteria
* CVD or diabetes
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Systolic blood pressure (SBP) | post 6 weeks intervention | SBP reduction in mmHg |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Diastolic blood pressure (DBP) | post 6 weeks intervention | DBP reduction in mmHg |
| low density lipoprotein cholesterol (LDL) | post 6 weeks intervention | LDL reduction in mg/dl |
| high density lipoprotein cholesterol (HDL) | post 6 weeks intervention | HDL reduction in mg/dl |
| triglycerides (TG) | post 6 weeks intervention | TG reduction in mg/dl |
| total cholesterol | post 6 weeks intervention | reduction in mg/dl |
Outcome results
None listed