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Motivational Interviewing and Neuroimaging With Adolescents

Motivational Interviewing and Neuroimaging With Adolescents

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03367858
Acronym
MINA
Enrollment
204
Registered
2017-12-11
Start date
2017-01-31
Completion date
2020-01-21
Last updated
2023-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alcohol Use, Unspecified

Brief summary

This is a randomized controlled trial to examine the impact of two brief interventions on adolescent and young adult alcohol use behaviors and related brain response. The interventions being compared are motivational interviewing (MI) and brief adolescent mindfulness (BAM).

Interventions

BEHAVIORALMotivational Interviewing (MI)

Motivational interviewing introduced a conversation about alcohol use, and the personally-experienced consequences of problem drinking. The MI sessions explored youths' stories around their substance use, the factors in youths' lives that support problem drinking (e.g., what they like about drinking), and the consequences of their recent or previous problem drinking (e.g., getting in trouble). Youth were provided personalized feedback about how their problem drinking compared to age-matched norms in the U.S. The ultimate goal of the MI sessions was to engage youth in a thoughtful conversation about their problem drinking with an eye to bolstering and supporting youths' own inherent drive for behavior change.

BEHAVIORALBrief Adolescent Mindfulness (BAM)

Brief Adolescent Mindfulness introduced a conversation about what mindfulness is, and ways that it might be personally-relevant to adolescents' current experiences. This manualized treatment introduced concepts of eastern thought in a manner articulated to adolescents. Treatment included a discussion of factors in the youth's life that could be positively impacted by using or engaging mindful approaches (e.g., current experiences of stress) and a link to how mindful approaches might be applicable or relevant to the adolescent's problem drinking. The ultimate goal was to engage youth in a thoughtful conversation about BAM and how eastern thought and mindful approaches could unburden some aspects of their current lived experiences.

Sponsors

University of Rhode Island
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
14 Years to 19 Years
Healthy volunteers
Yes

Inclusion criteria

* within the specified age range * \>= 1 past two month binge drinking episode * right-handed * proficient in English * agree to be contacted for the 3, 6, and 12 month follow ups * informed consent of a parent/guardian, if under 18 years old * informed assent/consent of participating youth

Exclusion criteria

* \> 3 past-month instances of non-nicotine and/or non-cannabis substance use (e.g., methamphetamine) * evidence of brain injury/illness or neurological disorder including psychosis * lifetime loss of consciousness \>= 2 min * unremovable metal on/in body, or other functional magnetic resonance imaging (fMRI) contraindications (e.g., pregnancy)

Design outcomes

Primary

MeasureTime frameDescription
Alcohol-related Problemsassessed at baseline, and 3-, 6-, and 12-month post-treatment follow ups; 12-month follow up reportedRutgers Alcohol Problems Index (RAPI) to assess alcohol-related problems. Minimum individual value = 0; maximum individual value = 92. Higher scores mean more alcohol-related problems.

Countries

United States

Participant flow

Participants by arm

ArmCount
Motivational Interviewing (MI)
This randomly assigned group receives two 60-minute 1:1 sessions of motivational interviewing.
101
Brief Adolescent Mindfulness (BAM)
This randomly assigned group receives two 60-minute 1:1 sessions of Brief Adolescent Mindfulness.
103
Total204

Withdrawals & dropouts

PeriodReasonFG000FG001
12 Month Follow UpLost to Follow-up33
12 Month Follow UpWithdrawal by Subject01
3 Month Follow UpIncarcerated01
3 Month Follow UpLost to Follow-up83
3 Month Follow UpMoved out of study area26
3 Month Follow UpMRI contraindication21
3 Month Follow UpUnable to adhere to session timeline13
3 Month Follow UpWithdrawal by Subject30
6 Month Follow UpLost to Follow-up52
6 Month Follow UpWithdrawal by Subject01
Intervention + Baseline ScanUnable to adhere to session timeline22
Intervention + Baseline ScanWithdrawal by Subject20

Baseline characteristics

CharacteristicMotivational Interviewing (MI)Brief Adolescent Mindfulness (BAM)Total
Age, Continuous18.83 years
STANDARD_DEVIATION 1.03
18.54 years
STANDARD_DEVIATION 1.08
18.68 years
STANDARD_DEVIATION 1.06
Alcohol-related Problems8.98 units on a scale
STANDARD_DEVIATION 13.08
6.13 units on a scale
STANDARD_DEVIATION 6.6
7.54 units on a scale
STANDARD_DEVIATION 10.4
Ethnicity (NIH/OMB)
Hispanic or Latino
21 Participants13 Participants34 Participants
Ethnicity (NIH/OMB)
Not Hispanic or Latino
79 Participants89 Participants168 Participants
Ethnicity (NIH/OMB)
Unknown or Not Reported
1 Participants1 Participants2 Participants
Race (NIH/OMB)
American Indian or Alaska Native
2 Participants1 Participants3 Participants
Race (NIH/OMB)
Asian
8 Participants12 Participants20 Participants
Race (NIH/OMB)
Black or African American
2 Participants4 Participants6 Participants
Race (NIH/OMB)
More than one race
11 Participants15 Participants26 Participants
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
2 Participants3 Participants5 Participants
Race (NIH/OMB)
Unknown or Not Reported
5 Participants4 Participants9 Participants
Race (NIH/OMB)
White
71 Participants64 Participants135 Participants
Region of Enrollment
United States
101 participants103 participants204 participants
Sex/Gender, Customized
Female
63 Participants62 Participants125 Participants
Sex/Gender, Customized
Genderqueer / Gender neutral
4 Participants6 Participants10 Participants
Sex/Gender, Customized
Male
33 Participants34 Participants67 Participants
Sex/Gender, Customized
Transgender
1 Participants1 Participants2 Participants

Adverse events

Event typeEG000
affected / at risk
EG001
affected / at risk
deaths
Total, all-cause mortality
0 / 1010 / 103
other
Total, other adverse events
0 / 1010 / 103
serious
Total, serious adverse events
0 / 1010 / 103

Outcome results

Primary

Alcohol-related Problems

Rutgers Alcohol Problems Index (RAPI) to assess alcohol-related problems. Minimum individual value = 0; maximum individual value = 92. Higher scores mean more alcohol-related problems.

Time frame: assessed at baseline, and 3-, 6-, and 12-month post-treatment follow ups; 12-month follow up reported

Population: Youth with full problem drinking data at all follow up time points were included in treatment outcome analyses.

ArmMeasureValue (MEAN)Dispersion
Motivational Interviewing (MI)Alcohol-related Problems2.75 units on a scaleStandard Error 0.45
Brief Adolescent Mindfulness (BAM)Alcohol-related Problems4.88 units on a scaleStandard Error 0.75
Comparison: We conducted a repeated measures ANCOVA of Time (Post-Treatment: 3, 6, 12 months) × Treatment (MI, BAM) with the covariate of pre-treatment problem drinking.p-value: 0.0173ANCOVA

Source: ClinicalTrials.gov · Data processed: Feb 13, 2026