Alcohol Use, Unspecified
Conditions
Brief summary
This is a randomized controlled trial to examine the impact of two brief interventions on adolescent and young adult alcohol use behaviors and related brain response. The interventions being compared are motivational interviewing (MI) and brief adolescent mindfulness (BAM).
Interventions
Motivational interviewing introduced a conversation about alcohol use, and the personally-experienced consequences of problem drinking. The MI sessions explored youths' stories around their substance use, the factors in youths' lives that support problem drinking (e.g., what they like about drinking), and the consequences of their recent or previous problem drinking (e.g., getting in trouble). Youth were provided personalized feedback about how their problem drinking compared to age-matched norms in the U.S. The ultimate goal of the MI sessions was to engage youth in a thoughtful conversation about their problem drinking with an eye to bolstering and supporting youths' own inherent drive for behavior change.
Brief Adolescent Mindfulness introduced a conversation about what mindfulness is, and ways that it might be personally-relevant to adolescents' current experiences. This manualized treatment introduced concepts of eastern thought in a manner articulated to adolescents. Treatment included a discussion of factors in the youth's life that could be positively impacted by using or engaging mindful approaches (e.g., current experiences of stress) and a link to how mindful approaches might be applicable or relevant to the adolescent's problem drinking. The ultimate goal was to engage youth in a thoughtful conversation about BAM and how eastern thought and mindful approaches could unburden some aspects of their current lived experiences.
Sponsors
Study design
Eligibility
Inclusion criteria
* within the specified age range * \>= 1 past two month binge drinking episode * right-handed * proficient in English * agree to be contacted for the 3, 6, and 12 month follow ups * informed consent of a parent/guardian, if under 18 years old * informed assent/consent of participating youth
Exclusion criteria
* \> 3 past-month instances of non-nicotine and/or non-cannabis substance use (e.g., methamphetamine) * evidence of brain injury/illness or neurological disorder including psychosis * lifetime loss of consciousness \>= 2 min * unremovable metal on/in body, or other functional magnetic resonance imaging (fMRI) contraindications (e.g., pregnancy)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Alcohol-related Problems | assessed at baseline, and 3-, 6-, and 12-month post-treatment follow ups; 12-month follow up reported | Rutgers Alcohol Problems Index (RAPI) to assess alcohol-related problems. Minimum individual value = 0; maximum individual value = 92. Higher scores mean more alcohol-related problems. |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Motivational Interviewing (MI) This randomly assigned group receives two 60-minute 1:1 sessions of motivational interviewing. | 101 |
| Brief Adolescent Mindfulness (BAM) This randomly assigned group receives two 60-minute 1:1 sessions of Brief Adolescent Mindfulness. | 103 |
| Total | 204 |
Withdrawals & dropouts
| Period | Reason | FG000 | FG001 |
|---|---|---|---|
| 12 Month Follow Up | Lost to Follow-up | 3 | 3 |
| 12 Month Follow Up | Withdrawal by Subject | 0 | 1 |
| 3 Month Follow Up | Incarcerated | 0 | 1 |
| 3 Month Follow Up | Lost to Follow-up | 8 | 3 |
| 3 Month Follow Up | Moved out of study area | 2 | 6 |
| 3 Month Follow Up | MRI contraindication | 2 | 1 |
| 3 Month Follow Up | Unable to adhere to session timeline | 1 | 3 |
| 3 Month Follow Up | Withdrawal by Subject | 3 | 0 |
| 6 Month Follow Up | Lost to Follow-up | 5 | 2 |
| 6 Month Follow Up | Withdrawal by Subject | 0 | 1 |
| Intervention + Baseline Scan | Unable to adhere to session timeline | 2 | 2 |
| Intervention + Baseline Scan | Withdrawal by Subject | 2 | 0 |
Baseline characteristics
| Characteristic | Motivational Interviewing (MI) | Brief Adolescent Mindfulness (BAM) | Total |
|---|---|---|---|
| Age, Continuous | 18.83 years STANDARD_DEVIATION 1.03 | 18.54 years STANDARD_DEVIATION 1.08 | 18.68 years STANDARD_DEVIATION 1.06 |
| Alcohol-related Problems | 8.98 units on a scale STANDARD_DEVIATION 13.08 | 6.13 units on a scale STANDARD_DEVIATION 6.6 | 7.54 units on a scale STANDARD_DEVIATION 10.4 |
| Ethnicity (NIH/OMB) Hispanic or Latino | 21 Participants | 13 Participants | 34 Participants |
| Ethnicity (NIH/OMB) Not Hispanic or Latino | 79 Participants | 89 Participants | 168 Participants |
| Ethnicity (NIH/OMB) Unknown or Not Reported | 1 Participants | 1 Participants | 2 Participants |
| Race (NIH/OMB) American Indian or Alaska Native | 2 Participants | 1 Participants | 3 Participants |
| Race (NIH/OMB) Asian | 8 Participants | 12 Participants | 20 Participants |
| Race (NIH/OMB) Black or African American | 2 Participants | 4 Participants | 6 Participants |
| Race (NIH/OMB) More than one race | 11 Participants | 15 Participants | 26 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 2 Participants | 3 Participants | 5 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 5 Participants | 4 Participants | 9 Participants |
| Race (NIH/OMB) White | 71 Participants | 64 Participants | 135 Participants |
| Region of Enrollment United States | 101 participants | 103 participants | 204 participants |
| Sex/Gender, Customized Female | 63 Participants | 62 Participants | 125 Participants |
| Sex/Gender, Customized Genderqueer / Gender neutral | 4 Participants | 6 Participants | 10 Participants |
| Sex/Gender, Customized Male | 33 Participants | 34 Participants | 67 Participants |
| Sex/Gender, Customized Transgender | 1 Participants | 1 Participants | 2 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | 0 / 101 | 0 / 103 |
| other Total, other adverse events | 0 / 101 | 0 / 103 |
| serious Total, serious adverse events | 0 / 101 | 0 / 103 |
Outcome results
Alcohol-related Problems
Rutgers Alcohol Problems Index (RAPI) to assess alcohol-related problems. Minimum individual value = 0; maximum individual value = 92. Higher scores mean more alcohol-related problems.
Time frame: assessed at baseline, and 3-, 6-, and 12-month post-treatment follow ups; 12-month follow up reported
Population: Youth with full problem drinking data at all follow up time points were included in treatment outcome analyses.
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Motivational Interviewing (MI) | Alcohol-related Problems | 2.75 units on a scale | Standard Error 0.45 |
| Brief Adolescent Mindfulness (BAM) | Alcohol-related Problems | 4.88 units on a scale | Standard Error 0.75 |