Influenza, PV Leukocidin, Staphylococcus Aureus Pneumonia
Conditions
Keywords
influenza, Staphylococcus Aureus, Pneumonia, PV leukocidin, ICU
Brief summary
Secondary bacterial influenza pneumonia caused by Panton-Valentine Leukocidin Positive Staphylococcus aureus is a rare complication but with poor prognosis. This pathology seems to affect young patients (20-40 years) without any medical history. Since the influenza pandemic of 2009, this complication is more and more mentioned, sought and diagnosed. However, the literature is poor, consisting of case reports, experimental studies on murine models, and low-power studies. The main objective is to evaluate the mortality in intensive care units of patients post-influenza bacterial pneumonia due to a Panton-Valentine Leukocidin positive Staphylococcus aureus
Interventions
None listed
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient treated for post-influenza bacterial pneumonia due to a Panton-Valentine Leukocidin positive Staphylococcus aureus in intensive care unit
Exclusion criteria
* Minor patient * Patient under protective measurement * Absence of bacteriological and / or virological documentation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of dead patients | During Length of stay in intensive care unit (an average of 2 weeks) | All cause of mortality |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical data in the initial phase relating to chills | During Length of stay in intensive care unit (an average of 2 weeks) | chills |
| Demographic data relating to age | Baseline | age |
| Demographic data relating to sex | Baseline | sex |
| Respiratory failure | Baseline | PaO2/iFO2 value |
| Demographic data relating to immunosuppression | Baseline | Amount of polynuclear neutrophils (G/L) |
| risk factors for methicillin-resistant Staphylococcus aureus | Baseline | hospitalization |
| Clinical data relating to pre-admission antibiotics | Baseline | type of antibiotic prescribed |
| Clinical data in the initial phase relating to SAPS 2 score | Baseline | Simplified acute Physiology score (SAPS2) score between 0 and 163 and a predicted mortality between 0% and 100% |
| Clinical data in the initial phase relating to SOFA admission | Baseline | Sequential Organ Failure Assessment (SOFA) |
| Clinical data in the initial phase relating to neutropenia | During Length of stay in intensive care unit (an average of 2 weeks) | neutropenia |
| Clinical data in the initial phase relating to metabolic acidosis | During Length of stay in intensive care unit (an average of 2 weeks) | metabolic acidosis |
| Clinical data in the initial phase relating to oxygen dependence | During Length of stay in intensive care unit (an average of 2 weeks) | oxygen dependence |
| Clinical data in the initial phase relating to headhache | During Length of stay in intensive care unit (an average of 2 weeks) | headache |
| Clinical data in the initial phase relating to productive cough | During Length of stay in intensive care unit (an average of 2 weeks) | productive cough |
| Clinical data in the initial phase relating to dyspnoea | During Length of stay in intensive care unit (an average of 2 weeks) | dyspnoea |
| Clinical data in the initial phase relating to acute respiratory failure | During Length of stay in intensive care unit (an average of 2 weeks) | acute respiratory failure |
| Clinical data in the initial phase relating to hyperthermia | During Length of stay in intensive care unit (an average of 2 weeks) | hyperthermia |
| Clinical data in the initial phase relating to uni - or multi - lobar infiltration on chest X - ray or CT scan | During Length of stay in intensive care unit (an average of 2 weeks) | uni - or multi - lobar infiltration on chest X - ray or CT scan |
| Clinical data in the initial phase relating to pleural effusion | During Length of stay in intensive care unit (an average of 2 weeks) | pleural effusion |
| Clinical data in the initial phase | During Length of stay in intensive care unit (an average of 2 weeks) | necrotizing pneumonitis |
| Clinical data in the initial phase relating to renal failure | During Length of stay in intensive care unit (an average of 2 weeks) | renal failure according to KDIGO classification |
| Prognostic factors for this pathology | During Length of stay in intensive care unit (an average of 2 weeks) | Time to diagnosis of influenza infection and Panton-Valentine Leukocidin Positive Staphylococcus aureus Haemoptysis, leukopenia, thrombocytopenia, acute respiratory distress syndrome (ARDS), PaO2 / Fi02, inotropic support |
| Complications | During Length of stay in intensive care unit (an average of 2 weeks) | Complications related to Septic shock ARDS: according to Berlin 2009 classification Extra corporeal vein-venous or veino-arterial oxygenation membrane (ECMO VV or ECMO VA) Ischemic limb Pneumothorax Acute renal failure according to Kdigo classification Disseminated intravascular coagulation (DIC) (2) Cardiogenic shock / cardiogenic pulmonary acute edema Multi visceral failure syndrome (3) Use of surgery: abscess drainage, lobectomy, amputation, laparotomy and colonic resection ... |
| Collection of infectious samples | During Length of stay in intensive care unit (an average of 2 weeks) | Bacteriological, Parasitological, Virological |
| Probabilistic antibiotherapy | During Length of stay in intensive care unit (an average of 2 weeks) | Collection of probabilistic antibiotherapy |
| Prescribed antibiotic therapy | During Length of stay in intensive care unit (an average of 2 weeks) | Collection of Prescribed antibiotic therapy |
| Collection of the date of introduction of adapted antibiotic therapy | During Length of stay in intensive care unit (an average of 2 weeks) | Collection of the date of introduction of adapted antibiotic therapy |
| Number of patients with Influenza type A | During Length of stay in intensive care unit (an average of 2 weeks) | Number of patients with Influenza type A |
| Number of patients with Influenza type B | During Length of stay in intensive care unit (an average of 2 weeks) | Number of patients with Influenza type B |
| Date of initiation of anti-viral treatment in relation to the onset of symptoms and duration of anti-viral treatment | During Length of stay in intensive care unit (an average of 2 weeks) | Date of initiation of anti-viral treatment in relation to the onset of symptoms and duration of anti-viral treatment |
| Dosage of antiviral treatment | During Length of stay in intensive care unit (an average of 2 weeks) | Dosage of antiviral treatment |
| Number of serious influenza infections per year and per center with early and late deaths | During Length of stay in intensive care unit (an average of 2 weeks) | Mortality caused by serious inflenza infections |
| Clinical data in the initial phase relating to hemoptysis | During Length of stay in intensive care unit (an average of 2 weeks) | hemoptysis |
Countries
France
Outcome results
None listed