Overweight and Obesity
Conditions
Brief summary
The aim of this study is to evaluate whether the longitudinal interaction between APOA5 -1131C variants and overweight could accelerate age-related increases in arterial stiffness and circulating triglycerides in healthy subjects.
Interventions
GENETICrs662799 (APOA5 -1131T>C)
Among the 349 normal-weight individuals, 168 were homozygous (TT) for the T allele, 155 were heterozygous for the C allele (TC) and 26 were homozygous (CC) for the C allele of the APOA5 -1131T\>C polymorphism. Among the 154 overweight individuals, 68 were homozygous (TT) for the T allele, 75 were heterozygous for the C allele (TC) and 11 were homozygous (CC) for the C allele of the APOA5 -1131T\>C polymorphism.
Sponsors
Yonsei University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Nondiabetic (fasting serum glucose concentration \< 126 mg/dL) * Nonobese (BMI ≥ 25 kg/m2)
Exclusion criteria
* Current and/or past history of cardiovascular disease * Diabetes mellitus (fasting glucose levels ≥126 mg/dL) * Abnormal liver or renal function * Thyroid or pituitary disease * Pregnancy or lactation * Regular use of any medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Brachial-ankle PWV (baPWV) | at baseline | cm/s |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Triglyceride | at baseline | mg/dL |
Outcome results
None listed