Interaction of Potassium and Genetic Risk Variants on Diabetes Risk

Interaction of Potassium Measures With Potassium Channel Genetic Variants on Diabetes Risk: The Atherosclerosis Risk in Communities (ARIC) Study and Jackson Heart Study (JHS)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03367455

Enrollment

11812

Registered

2017-12-08

Start date

2015-05-31

Completion date

2017-11-30

Last updated

2017-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes

Keywords

Potassium, Genetic Variants

Brief summary

The investigators propose to study the association of the KCNJ11 (Potassium Voltage-Gated Channel Subfamily J Member 11) polymorphisms on diabetes risk in the Atherosclerosis Risk in Communities (ARIC) and Jackson Heart Study (JHS) cohorts. The investigators also propose to test for an interaction between serum K and these genetic variants. By testing for such an interaction, it will be determined if, among participants with these genetic variants, a low-normal serum K was a stronger predictor of diabetes risk compared to those participants without these genetic variants.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Member of the Atherosclerosis Risk in Communities (ARIC) Study or Jackson Heart Study (JHS) cohorts

Exclusion criteria

* Had not fasted 8 or more hours for the baseline visit * Prevalent diabetes at baseline exam * Missing information on serum potassium * Missing single nucleotide polymorphism (SNP) data * Evidence of kidney dysfunction * Race other than black/African American or white/Caucasian * Missing other covariates

Design outcomes

Primary

Measure	Time frame	Description
Associations of serum potassium and KCNJ11 variants with incident diabetes as represented by odds ratio	through study completion, mean of 8 years of follow-up	Calculation of odds ratio will be used to represent the risk of incident diabetes associated with serum K, rs5215, and rs5219 within the cohort

Outcome results