Congenital Heart Disease, Infant, Premature, Diseases
Conditions
Keywords
sevoflurane, S100β protein, regional cerebral oxygen saturation, infant
Brief summary
To observe the effect of sevoflurane on the concentration of S100β and regional cerebral oxygen saturation in infants with congenital heart disease undergoing cardiac surgery.
Interventions
DRUGSevoflurane
1.5%-3% Sevoflurane will be given during the cardiac surgery except cardiopulmonary bypass.
Sponsors
Jun Ma
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
one group is treated with sevoflurane, the other is not.
Eligibility
Sex/Gender
ALL
Age
No minimum to 3 Years
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of congenital heart disease * Undergoing heart surgery with cardiopulmonary bypass
Exclusion criteria
* Pulmonary arterial hypertension * Sevoflurane allergy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Concentration of S100β protein | 5 minutes after tracheal intubation; immediately after cardiopulmonary bypass; immediately after operation; 12 hours, 24 hours postoperative | The concentration of S100β protein was performed using the electrochemiluminescence immunoassay.(Blood samples from patients were drawn from central intravenous.) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Level of regional cerebral oxygen saturation(rScO2) | 5 minutes after tracheal intubation; immediately after cardiopulmonary bypass; immediately after operation; 12 hours, 24 hours postoperative | The rScO2 was measured by using noninvasive near-infrared spectroscopy during cardiac surgery |
Countries
China
Contacts
Primary ContactJun Ma, M.D.,phD
Outcome results
None listed