Circadian Rhythm, Controlled Ovarian Stimulation, Oocyte Donors, Progesterone Variation on Trigger Day
Conditions
Brief summary
The current study, aims through a robust design to provide a simple answer on whether progesterone levels of the same individual may significantly vary depending on the time of blood retrieval before the ovulation triggering, by evaluating the daily variability of serum progesterone on the day of triggering in healthy women who perform a COS for oocyte donation, through multiple blood samplings.
Interventions
DIAGNOSTIC_TESTSerum progesterone measure
Serum Progesterone will be measured in all donors on the day triggering at 8:00 am, 12:00 p, 16:00 pm and 20:00 pm
Sponsors
Fundacion Dexeus
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy oocyte donors according to spanish law for oocyte donation * Controlled ovarian stimulation following a flexible antagonist protocol and stimulation with recombinant Follicular stimulating hormone. * Informed consent signed
Exclusion criteria
* Detection of luteinizing hormone surge before triggering
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Progesterone variation among 4 different moments on the day of ovulation triggering | Progesterone will be measured 4 times on the day of ovulation triggering, each of them separated 4 hours from the previous one (total 4 samples within 12 hours): blood samples will be obtained at 8:00 am, 12:00 pm, 4:00 pm and 08:00 pm | Measurement of serum Progesterone (ng/ml) in each oocyte donor at 4 different times on the day of ovulation triggering: The primary outcome will be the variation among the 4 progesterone measurements for each patient within the fixed12 hours time (8:00am; 12:00pm; 4:00pm and 8:00pm). |
Countries
Spain
Outcome results
None listed