Arthropathy of Hip, Arthropathy of Knee
Conditions
Keywords
Periprosthetic Joint Infection
Brief summary
This retrospective study aims to improve the diagnosis of PJI as well as to identify microorganisms causing periprosthetic joint infection (PJI) and the drug-resistant spectrum
Detailed description
160 patients who underwent revision or re-revision total hip or knee arthroplasty for different reasons in our institution were recruited from August 2013 to August 2016. 80 patients meet the criteria of PJI from the muscle and skeletal muscle Association (MSIS) are divided to the infection group, another 80 patients are divided into the non-infection group. Medical and demographic data were recorded. Collected lab examinations included blood routine test, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), synovial leukocyte counts, Receiver Operating Characteristic Curve-Area Under Curve (ROC-AUC) analysis will be used to evaluate the specific and sensitivity of diagnosis index. Moreover,microorganisms isolated from periprosthetic tissues and articular fluid. Postoperatively, the prosthesis was sent for ultrasound sonication. The sonicate extraction, implant surrounding tissue and synovium were sent for microbiologic culture, and the implant-surrounding-tissue were also sent for pathological examination. The isolated strains and drug-resistance rate for each bacterium for different antibiotics were presented.
Interventions
OTHERPeriprosthetic Joint Infection
Periprosthetic Joint Infection is diagnosed according to the diagnosing criteria from the Workgroup of the Musculoskeletal Infection Society.
OTHERNon-Periprosthetic Joint Infection
PJI can not be diagnosed for the lack of clinical evidence according to the diagnosing criteria from the Workgroup of the Musculoskeletal Infection Society.
Sponsors
Peking University People's Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* patient who underwent revision or re-revision total hip or knee arthroplasty for different reasons in our institution
Exclusion criteria
1. Patients who refused to join the trial group; 2. Revision total hip/knee replacement for periprosthetic fracture; 3. patients who missed some of important examination; 4. Revision total hip/knee replacement for metal sensitivity; 5. Revision total hip/knee replacement for the last period of second-stage revision; 6. Patient who underwent revision with RA or other inflammatory disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation the specific and sensitivity of CRP | within 4 weeks before the operation | To test the specifity and sensitivity of CRP |
| Evaluation the specific and sensitivity of ESR | within 4 weeks before the operation | To test the specifity and sensitivity of ESR |
| Evaluation the specific and sensitivity of synovial leukocyte counts | within 4 weeks before the operation | To test the specifity and sensitivity of synovial leukocyte counts |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Microorganisms identification and the | within 4 weeks before the operation | Identify microorganisms causing periprosthetic joint infection (PJI) as well as the drug-resistant spectrum. |
| Drug-resistant spectrum. | within 4 weeks before the operation | Identify the drug-resistant spectrum of the microorganisms. |
Contacts
Primary ContactZhanglai Li
Outcome results
None listed