Partial Least Squares Regression Modelling for Glaucoma Detection

Partial Least Squares Regression Modelling for Glaucoma Detection Using Retinal Nerve Fiber Layer, Ganglion Cell Layer and Visual Field Data

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03365245

Enrollment

Registered

2017-12-07

Start date

2015-08-31

Completion date

2016-11-30

Last updated

2017-12-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glaucoma

Brief summary

A partial least squares regression model for visual field testing among glaucoma patients will be developed. In addition, microperimetry will be compared to conventional perimetry and reproducibility will be assessed.

Detailed description

Aim of this study is to develop a partial least squares regression model incorporating retinal nerve fiber layer (RNFL) and retinal ganglion cell layer (RGCL) measurements as well as visual field testing to represent a glaucoma expert opinion on the stage of glaucoma. In addition, microperimetry will be compared to conventional perimetry and reproducibility will be assessed.

Interventions

DEVICEMicroperimetry

Microperimetry is performed at three different days

DEVICEautomated visual field

Automated visual field ist performed at three different days

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

21 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age 21 and older * written informed consent prior to surgery * any glaucoma-associated changes in one or both eyes (i.e. increased intraocular pressure, optic disc changes, known visual field defects) in the glaucoma patients and the absence of any glaucoma associated changes in the healthy eyes group.

Exclusion criteria

* Secondary glaucoma * In case of pregnancy (pregnancy test will be taken in women of reproductive age)

Design outcomes

Primary

Measure	Time frame	Description
partial least square regression	one month	Development of a partial least squares regression model to detect glaucoma

Secondary

Measure	Time frame	Description
reproducibility	one month	Comparison of reproducibility of microperimetry and visual field testing
Retinal nerve fiber thickness (RNFL) and the the retinal ganglion cell layer (RGCL)	one month	The retinal nerve fiber layer thickness and the thickness of the retinal ganglion cell layer will be compared
Microperimetry versus visual field testing	one month	Comparison of microperimetry and visual field testing

Countries

Austria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026