Influencing Factors on Dry Eye Syndrome and Ocular Surface Disease

Prospective Study for Influencing Factors on Dry Eye Syndrome, Ocular Surface Disease and Treatment

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03364322

Enrollment

200

Registered

2017-12-06

Start date

2016-06-01

Completion date

2017-06-30

Last updated

2017-12-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dry Eye Syndrome, Ocular Surface Disease

Brief summary

Dry eye syndrome and ocular surface disease are very important ophthalmologic diseases. It is known that various inducers are involved. However, it is still necessary to study how influencing factors are related to dry eye syndrome and ocular surface disease and how treatment for dry eye syndrome and ocular surface disease is helpful.

Interventions

OTHERObservation

Observation

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

19 Years to 79 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients with ocular discomfort related to DED who visit the Hallym University Kangnam Sacred Heart Hospital between June 2016 and June 2017.

Exclusion criteria

* Subjects who are elderly (≥80 years old) or have an autoimmune disease (e.g., Sjögren's syndrome and systemic lupus erythematosus) are excluded.

Design outcomes

Primary

Measure	Time frame	Description
Ocular surface disease index	1 day	The ocular surface disease index survey in completed at the time of the exam. This scale ranges from 0 to 100 higher scores representing greater disability.

Secondary

Measure	Time frame	Description
Tear break-up time	1 day	—
Schirmer tear secretion test	1 day	Schirmer tear secretion test (mm) without anesthesia was performed using strip (Color Bar; Eagle vision. Memphis, TN)
Corneal fluorescence staining	1 day	Corneal staining with fluorescein solution is graded at the time of the exam on a scale of 0 to 5 using the oxford scoring system with 5 being the most severe staining.

Other

Measure	Time frame	Description
Tear osmolarity	1 day	The tear film osmolarity (mOsm) is measured using TearLab (TearLab Co., San Diego, CA).
modification of SPEED score	1 day	SPEED score using questionnaire indicates a higher level of discomfort.
Eyelid hyperemia	1 day	Graded as follows. 0=none, 1= mild, 2=mod, and 3=severe
Conjunctivochalasis	1 day	Graded as follows. 0=none, 1= mild, 2=mod, and 3=severe fixed fold
visual analogue pain score	1 day	visual analogue pain score indicates a higher level of discomfort. 0 to 10.

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026