Infection, Intensive Care Unit, Liver Transplantation, Sepsis
Conditions
Brief summary
Despite major advances, infections remain one of the major causes of morbidity and mortality in patients undergoing orthotopic liver transplantation (OLT). Furthermore, data on the epidemiology, severity, and type of post-OLT infections nowadays available come from dated, monocentric, retrospective series. Finally, there is no available data focused on the critical OLT patient admitted to the Intensive Care Unit (ICU). Therefore this study was conceived (1) to describe incidence, severity, epidemiology and outcomes of infections recorded in OLT patients in the ICU (first or re-admission ); (2) to identify possible risk factors and (3) to report the type of the involved microorganism with their antibiotic sensitivity pattern
Detailed description
The study will record clinical, epidemiological and microbiological data from the clinical files of OLT patients admitted at italian ICUs
Interventions
None listed
Sponsors
Azienda Ospedaliero, Universitaria Pisana
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Inclusion criteria
1. Age\> 18 aa 2. Sex: Both 3. written consent to participate in the study 4. having been undergone to OLT in the 10 years prior to enrollment 5. Infection diagnosis (any type, any localization, any agent) 6. Being admitted in the ICU
Exclusion criteria
1. Death within 72 hours of admission 2. Withdrawal of consent \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical | 18 months | number and severity of infectious episodes |
| microbiological | 18 months | describe the type of infectious agents |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Resistance | 18 months | antibiotic resistance patters of the isolates |
Countries
Italy
Outcome results
None listed