Bladder Cancer, Sarcopenia
Conditions
Keywords
physical activity, elderly
Brief summary
Sarcopenia is associated with lower prognosis in solid tumors, but this has not been studied in bladder carcinoma requiring cystectomy. According to EWGSOP recommendations, the diagnosis of sarcopenia is based on walking speed, grip strength and muscle mass. These three elements can easily be measured (specially muscle mass measurement by bioimpedencemetry or tomodensitometry). This cohort study will collect clinical complementary elements to better understand the associated factors present with sarcopenia, in order to prepare an interventional preoperative physical reconditioning study. The mobility measurement will be carried out by the QAPPA questionnaire (validated in French in the elderly) and the quantitative measurement of activity and rest hours during a week by a wrist actimeter. Standardized geriatric data will also be collected: ADL, IADL for autonomy, MMSE for cognitive status, nutritional status (% weight loss, BMI), pain, GDS15 for depression screening, updated Charlson Comorbidity Index to identify polypathology and The STOPP tool for potentially inappropriate medication. Post-operative morbidity mortality at 30 days will be evaluated according to Clavien-Dindo classification. Investigators will also evaluate 6 months geriatric complications : falls, loss of autonomy and decreased mobility and physical activity, cognitive degradation, undernutrition, institutionalization
Interventions
DIAGNOSTIC_TESTsarcopenia and mobility measurement
walking speed, grip strength and BIA. QAPPA questionnaire (validated in French in the elderly) and the objective measurement of the time of activity and rest on a week per wrist actimeter. Comprehensive Geriatric Assessment
Sponsors
University Hospital, Caen
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* confirmed urothelial bladder carcinoma ( RTUV) * indication of radical cystectomy * Able, informed and with informed consent for the study * affiliated to the social security system * talking French
Exclusion criteria
* Life expectancy \<6 months * other active malignant tumors or other severe concomitant chronic pathologies affecting the general condition of the patient and / or likely to limit compliance with the requirements of the study. * treatments incompatible with the study: previous corticosteroid treatment prolonged for more than one month (induces iatrogenic sarcopenia).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| post-operative morbidity | at 30 days | evaluated according to Clavien-Dindo classification |
| post-operative mortality | at 30 days | — |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| post-operative complications | 8 months | Impact of dependancy (PS / ADL / IADL) |
| impedancemetric value | 2 months | Concordance of values (attribution of sarcopenic / non-sarcopenic groups) with impedancemetric value |
| sarcopenic status | between baseline; preoperative and at 6 months post-operative | evolution of sarcopenic status |
| quality of life scores | preoperative and 6-month post-operative | EORTC QLQ-ELD14 (assessment of health-related quality of life elderly patients with cancer with 14 items) |
Countries
France
Contacts
Primary Contactfrançois fournel
Backup Contacthelene legros
Outcome results
None listed