Measurement of Optic Nerve Sheath Diameter

Effect of Different Speed of Normal Saline Injection on Optic Nerve Sheath Diameter During Thoracic Epidural Catheterization

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03362255

Enrollment

Registered

2017-12-05

Start date

2017-11-13

Completion date

2018-05-05

Last updated

2018-07-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Optic Nerve Sheath Diameter

Keywords

Optic Nerve Sheath Diameter Injection Speed

Brief summary

It is reported that optic nerve sheath diameter increases when higher volume of medication is injected during epidural anesthesia. This study is designed to compare the optic nerve sheath diameter using 10cc of nomal saline of different speed (3cc/sec vs. 1cc/sec).

Detailed description

It is known that insufficient intraoperative or postoperative management can lengthen the hospital stay with unwanted complications. Therefore, active and proper management using continuous thoracic epidural catheterization is suggested good option to prevent such potential complication. According to previous study, injection of different volume of local anesthetics (1.0 ml/kg vs. 1.5 ml/kg) during caudal anesthesia, high volume of local anesthetics resulted in significant increase of intracranial pressure (ICP). Increase of ICP can reduce regional cerebral flow and oxygen saturation causing the safety of patients. In addition, increase of ICP can result in headache, syncope, and transient loss of visual acuity. Although it is very invasive method, ICP can be measured directly at the brain parenchyme. Among methods to measure the ICP indirectly, measurement of optic nerve sheath diameter using ultrasound is known to reflect the degree of ICP. It is reported that optic nerve sheath diameter increases when higher volume of medication is injected during epidural anesthesia. This study is designed to compare the optic nerve sheath diameter using 10cc of nomal saline of different speed (3cc/sec vs. 1cc/sec).

Interventions

OTHERthoracic epidural catheterization

thoracic epidural catheterization with different speed of injection

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 80 Years

Healthy volunteers

Inclusion criteria

* lung cancer * liver cancer * stomach cancer * pancreas cancer

Exclusion criteria

* coagulopathy * infection * previous spine fusion at thoracic level * previous brain surgery

Design outcomes

Primary

Measure	Time frame	Description
optic nerve sheath diameter change among 4 time period	Baseline, 1 minutes, 10 minutes, 30 minutes after the completion of the intervention	optic nerve sheath diameter change among 4 time period using ultrasound

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 2, 2026