Neck Pain
Conditions
Keywords
Conditioned pain modulation, neck pain
Brief summary
The aim of this study was to evaluate changes in local and segmental hypersensitivity and endogenous pain inhibition in people with chronic nonspecific neck pain.
Detailed description
Quantitative sensory testing is widely used in human research to investigate the state of the peripheral and central nervous system contributions in pain processing. It is a valuable tool to help identify central sensitization and may be important in the treatment of chronic neck pain. This study is a cross-sectional study. Two groups including chronic neck pain group and healthy volunteers group will be arranged in this study. The healthy subjects will be matched for sex and age in relation to the neck pain group. The pressure pain threshold (PPT) will be measured at the neck muscle in both groups. The cold pressor test will be used in both groups to activate conditioned pain modulation.
Interventions
OTHERPatients with chronic neck pain
Patients,aged 21-80 years, must have experienced neck pain for at least 3 months and have reported a minimal pain level of 30 (pain threshold) on the 0-100 pain numerical rating scale (NRS) in the last 7 days.
OTHERSubjects without chronic neck pain
Subjects,aged 21-80 years, must not have presented episodes of chronic neck pain for more than 7 days in the last 12 months.
Sponsors
Peking University People's Hospital
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
21 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
1. Chronic neck pain subjects Inclusion criteria: * Age 21-80 years old. * People must have experienced neck pain for at least 3 months and have reported a minimal pain level of 30 (pain threshold) on the 0-100 pain numerical rating scale (NRS) in the last 7 days.
Exclusion criteria
* Age under 21 or over 80. * Patients were excluded if they had taken pain medications on the day of the assessment or if they had serious spinal pathologies, such as fractures, tumors or inflammatory diseases, such as ankylosing spondylitis, nerve root compromise confirmed by clinical neurological tests or severe cardiorespiratory diseases. * Those who were pregnant, patients with cancer and those with a cardiac pacemaker were also excluded. 2. Healthy volunteers Inclusion criteria: * Age 21-80 years old. * These participants must not have presented episodes of low back pain for more than 7 days in the last 12 months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of pressure pain threshold (PPT) | The PPT will be measured before CPT, 30 seconds after the CPT begin, and immediately after CPT. | A cold pressor test (CPT) was used to induce pain and trigger the conditioned pain modulation (CPM) response. The conditioned stimulus was immersion of the leg in a bucket of ice water on the side ipsilateral to the most painful neck region. The neck PPT was recorded beginning 30 s after immersion of the leg with two PPT measures for each point. The PPT will be also measured again immediately after CPT. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Numerical rating scale for pain (NRS) | The patients used this scale to rate the pain intensity of the neck pain before the experiment. | The NRS evaluates levels of pain intensity using an 100-point scale (range 0-100), with 0 being classified as no sensation, 30 pain threshold, 100 pain as bad as could be. |
Countries
China
Contacts
Primary ContactWeiwei Xia, Ph.D.
Outcome results
None listed