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Colonoscopic Adenoma and Advanced Neoplasia Detection Rates According to Age

Adenoma and Advanced Neoplasia Detection Rates Increase From 45 Year of Age: Results of a Monocentric One-year Observational Cohort Study on 6027 Colonoscopies

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03361904
Enrollment
6027
Registered
2017-12-05
Start date
2016-01-01
Completion date
2016-12-31
Last updated
2017-12-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Age, Colon Adenoma, Colon Cancer, Colonic Polyp, Colonoscopy

Brief summary

Current recommendations for colonoscopy screening programs usually involve patients older than 50 years of age. However, little is known about polyp or adenoma detection rates under 50. We compared these detection rates according to age in a large series of patients in common practice. Methods: All colonoscopies performed in 2016 in our unit were prospectively recorded. We determined adenoma detection rate (ADR), polyp detection rate (PDR), mean number of polyps (MNP), and advanced neoplasia detection rate (ANDR).

Detailed description

Patients All consecutive patients who were scheduled for colonoscopy were included. Exclusion criteria were: patients scheduled for partial colonoscopy, interventional colonoscopy (for stent insertion, stenosis dilation). Data collection The following data have been prospectively collected: age, gender, indication for colonoscopy, preparation procedure and quality of the preparation (assessed by the Boston Bowel Preparation Scale; BBPS) \[19-20\], caecal intubation (yes/no), withdrawal time, number and size of polyps and polyp histopathology. All clinical data were collected during the procedure by a nurse and an endoscopist on a dedicated software. The database was then supplemented by the Clinical Research Associate for histopathological data. We determined adenoma detection rate (ADR; percentage of colonoscopies with at least one adenoma), polyp detection rate (PDR: percentage of colonoscopies with at least one polyp), mean number of polyps per colonoscopy (MNP), large polyp detection rate (LPDR; percentage of colonoscopies with at least one polyp of 1 cm or more) and advanced neoplasia detection rate (ANDR: percentage of colonoscopies with at least one advanced neoplastic lesion as defined below).

Interventions

PROCEDUREColonoscopy

Total colonoscopy : All consecutive patients who were scheduled for colonoscopy were included. Exclusion criteria were: patients scheduled for partial colonoscopy, interventional colonoscopy (for stent insertion, stenosis dilation).

Sponsors

Société Française d'Endoscopie Digestive
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
15 Years to 99 Years

Inclusion criteria

* All consecutive patients who were scheduled for colonoscopy were included.

Exclusion criteria

* patients scheduled for partial colonoscopy, interventional colonoscopy (for stent insertion, stenosis dilation).

Design outcomes

Primary

MeasureTime frameDescription
Adenoma detection rate according to ageduring colonoscopyADR \<30yo, in 30-34 yo, in 35-39yo, in 40-44yo, in 45-49yo, in 50-54yo, in 55-59yo, in 60-64yo, in 65-69 yo, in 70-74yo, in 75-79yo and \>79yo intervals
Advanced Neoplasia Detection rate according to ageduring colonoscopyANDR \<30yo, in 30-34 yo, in 35-39yo, in 40-44yo, in 45-49yo, in 50-54yo, in 55-59yo, in 60-64yo, in 65-69 yo, in 70-74yo, in 75-79yo and \>79yo intervals

Secondary

MeasureTime frameDescription
Indication for colonoscopyduring colonoscopypain / screening/ familial or personal history of polyp or cancer
quality of the preparationduring colonoscopyBoston Bowel Preparation Scale Segment Score Description 0: unprepared colon segment with mucosa not senn due to solid stool that cannot be cleared 1. Portion of mucosa of the colon segment seen, but other areas of the colon segment are not well seen due to staining, residual stool, and/or opaque liquid 2. minor amount of residual staining, small fragments of stool, and/or opaque liquid, but mucosa of colon segments is seen well 3. entire mucosa of colon segment seen well, with no residual staining, small fragments of stool or opaque liquid Total score is a summation of scores from three segments of the colon Score is from 0 to 9
Ageduring colonoscopyyears old
Withdrawal timeduring colonoscopyin seconds
Caecal intubationduring colonoscopyY/N
Genderduring colonoscopyMale or Female

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026