Healthy
Conditions
Keywords
physical activity, energy balance, caloric restriction, overfeeding, appetite regulation
Brief summary
Aim of the study is to investigate the impact of energy flux (achieved by changes in physical activity) under the conditions of energy balance, caloric restriction and overfeeding in healthy subjects.
Detailed description
A low energy flux is achieved by low energy expenditure, equivalent to low physical activity and with a corresponding low energy intake. A high energy flux is achieved by high energy expenditure, equivalent to high physical activity and with a corresponding high energy intake, respectively. The protocol of this randomized, intra-individual nutrition intervention includes 12 one-day interventions with 3 different levels of energy flux and 4 different diet conditions.
Interventions
BEHAVIORALphysical activity
3 different levels of physical activity
BEHAVIORALenergy intake
4 different types of energy intake
Sponsors
University of Hohenheim
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* 20-40 years of age * healthy * BMI between 18.5 and 31 kg/m2
Exclusion criteria
* smoking * food allergies * alternative nutrition habits like vegetarian / vegan * chronic diseases * regular medication intake * claustrophobia * weight loss \> 5 kg in the last 3 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| energy balance | 24 hours | difference between predefined energy balance and measured energy balance |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| ghrelin levels | every 2 hours during the day over 14 hours | area under the curve of total plasma ghrelin |
| arterial stiffness | 15 hours | pulse wave velocity |
Countries
Germany
Outcome results
None listed