Chronic Kidney Diseases
Conditions
Keywords
hemodialysis, dialytic clearance, pharmacokinetics
Brief summary
Eight maintenance hemodialysis patients are given one of four beta blocker drugs (atenolol, bisoprolol, carvedilol, metoprolol) three hours prior to a hemodialysis session. Blood samples and spent dialysate are collected during dialysis. On separate dialysis sessions, patients received the other study drugs until they have taken each of the four study drugs. Dialytic clearance is calculated.
Interventions
DRUGBeta blocker
Beta blockers are administered as described in arms.
Sponsors
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* at least 18 years of age, receiving hemodialysis three times per week for at least 90 days.
Exclusion criteria
* gastrointestinal or liver disease, body mass index greater than 40 kg/m2, contraindications for receiving a beta blocker (treatment with contraindicated medications, prior adverse reaction, severe reactive airway disease, hemodynamic instability during dialysis).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Dialytic Clearance | Through study completion, average of one year. | Dialytic clearance calculated by the recovery clearance method |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Dialytic Clearance | Through study completion, average of one year. | Dialytic clearance calculated by the arteriovenous difference method |
Outcome results
None listed