Comparing Effectiveness of Merocel and Packing With Tranexamic Acid in the Management of Anterior Epistaxis

The Evaluation of Effectiveness of Nasal Compression With Tranexamic Acid Compared to Simple Nasal Compression and Merocel Packing

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03360045

Enrollment

135

Registered

2017-12-02

Start date

2018-05-01

Completion date

2018-08-01

Last updated

2018-08-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epistaxis, Nasal Packing, Tranexamic Acid

Brief summary

Aim of this study is evaluate whether superior nasal compression with tranexamic acid to simple nasal compression and Merocel packing. In this study, patients who presented with non-traumatic anterior epistaxis to emergency departments will be included in this study. Three different therapy option are created; first, nasal compression with tranexamic acid, second, simple nasal compression without any drugs. And third, packing with Merocel.

Interventions

DRUGTranexamic Acid

500mg tranexamic acid is sprayed in the nose by atomizer spray, and then is applied nasal compression by manually.

DRUGNormal saline

5 cc normal saline is sprayed in the nose by atomizer spray, and then is applied nasal compression by manually.

DEVICEMerocel

Merocel packing is applied.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Patients with anterior epistaxis older than 18 year and accept to participate in the study

Exclusion criteria

* Patients younger than 18 years * Patients who used anticoagulation therapy * Patients who have hemodynamically instability * Traumatic epistaxis * Patients who have known bleeding disorder

Design outcomes

Primary

Measure	Time frame	Description
Success rate of interventions to stop bleeding	First 15 minutes	Percentages of numbers of patients who have stopped bleeding within first 15 minutes after nasal compression or Merocel packing
Numbers of patients who needs rescue treatment	After 15 minutes first intervention method.	In patients who have unstoppable epistaxis within 15 minutes, Merocel packing will be applied as a rescue treatment. Numbers of these patients will be recorded.

Secondary

Measure	Time frame	Description
Re-bleeding	24 hour	Frequency of re-bleeding within first 24 hours.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026