Conjunctival Diseases, Dry Eye Syndromes
Conditions
Keywords
Conjunctival Diseases, Dry Eye Syndromes, Antigens, CD147
Brief summary
Modifications of cell surface markers (including EMMPRIN) were observed in conjunctival epithelial cells during dry eye syndrome ; this study aims to describe the modifications of the repartition of these cell surface markers before and after initiation of a treatment.
Interventions
None listed
Sponsors
Fondation Ophtalmologique Adolphe de Rothschild
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patients: Inclusion criteria * 18 years and over * Severe eye dryness (grade 3 or 4) as defined by the International Dry Eye Work Shop (2007): Frequent symptoms, Impregnation of fluorescein at the conjunctival level, marked fluorescein staining at the corneal level, Tear Break Up Time ≤ 5 seconds (fluorescein test) Schirmer's test score without anesthesia ≤ 5mm at 5 minutes * Patients without eye treatment or patients undergoing long-term stable eye treatment for whom a new treatment is being introduced
Exclusion criteria
- Known pregnancy or breastfeeding Control subjects: Inclusion criteria \- 18 years and over
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| comparison of surface area of cell markers measured on conjunctival epithelial cells, in persons with and without severe eye dryness. | baseline | Comparison of the mean surface in patients before treatment for eye dryness versus in persons with no eye dryness. Immunofluorescence analysed in confocal microscopy on conjunctival impression cytology. |
Countries
France
Contacts
Primary ContactAmélie YAVCHITZ
Outcome results
None listed