Study on the Brain Network of Angelman Syndrome

Study on the Brain Network of Angelman Syndrome Based on Multi-modal Brain Image and Neural-EEG Data

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03358823

Enrollment

150

Registered

2017-12-02

Start date

2017-05-20

Completion date

2019-05-20

Last updated

2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Angelman Syndrome

Keywords

AS database, MRI, EEG

Brief summary

The aims of study on Angelman syndrome: 1. Establish the Angelman syndrome database 2. Explore the brain Network of Angelman Syndrome Based on Multi-modal Brain Image and Neural-EEG Data

Detailed description

1. The participants recruitment: from Chinese Angelman Syndrome Patients group (Angelhome : angelman225@126.com) and Children's Hospital of Fudan University. 2. Fistly all participants had clinically and molecularly confirmed as Angelman syndrome . All participants should entry the online questionnaries and carified by telephone or on site . All the information will be recorded in the Angelman syndrome database. Investigators will analyze and summarize the relationship of phenotype and genotype(n=200). 3. Participants who assigned the informed consent and will undergo the brain MRI inspection and Neural-EEG recording in the Children's Hospital of Fudan University. The healthy age- and sex-matched control participants will enrolled in the same hospital. The Investigators will explore the brain morphology and electrophysiological alterations and for Angelman syndrome (AS) children among the different genotypes（n=200）.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

No minimum to 18 Years

Healthy volunteers

Yes

Inclusion criteria

* Clinical and molecular diagnosis of Angelman syndrome. * Agreed and completed the MRI scan and EEG-recording by using oral chloral hydrate.

Exclusion criteria

* Reject MRI scan and EEG-recording by using oral chloral hydrate or unable to complete the scan.

Design outcomes

Primary

Measure	Time frame	Description
Angelman syndrome databas; Brain Network of Angelman syndrome	0-18 years old	1. Analysis of geneal situation of Chinese Angelman syndrome including phenotype ,genotype, brain image ,EEG data, living quality ,comorbidy evolulation(n=200) 2. Study on the Brain Network of Angelman Syndrome Based on Multi-modal Brain Image and Neural-EEG Data

Countries

China

Outcome results