Osteoarthritis, Knee
Conditions
Keywords
exercise, physical activity, radiographic osteoarthritis
Brief summary
Wuchuan Osteoarthritis Study is a population-based longitudinal study of natural history of knee osteoarthritis and its risk factors. At baseline and follow-up visits, IPA-Q questionnaire and a radiographs at tibiofemoral (TF) joints will be taken in order to assess the relationship between physical activity and radiographic osteoarthritis worsening.
Detailed description
1025 residents aged ≥ 50 years will be recruited using door-to-door enumeration in randomly selected rural communities in Wuchuan, China, and will be followed in 3 years. At baseline and follow-up visits, subjects will complete a home interview (including, but not limited to, socio-demographic factors, physical activity level using IPA-Q questionnaire,WOMAC questionnaire) and have a weight-bearing posteroanterior semiflexed view of radiographs at tibiofemoral (TF) joints. Radiographic osteoarthritis (ROA) worsening for a knee is defined if its Kellgren and Lawrence (K/L) grade increases by at least 1 grade except for the change from 0 to 1 during follow-up. The relationship between level of physical activity and ROA worsening will be assessed.
Interventions
According to the result of IPA-Q questionnaire, participants are divided in three groups: low level, moderate level, high level of physical activity.
Sponsors
Peking University People's Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Inclusion criteria
1. people aged 50 or over 2. Wuchuan permanent resident population
Exclusion criteria
1. patients with rheumatoid arthritis 2. the disabled 3. patients with mental disorders 4. laid up for malignant tumor 5. people who live or work outside for more than half a year
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| worsening of radiographic osteoarthritis | 3 years after enrollment | The tibiofemoral radiograph of both knee joint will be taken at baseline and in 3 years. Knee radiographs will be read by one investigator according to Kellgren and Lawrence (K/L) criteria. A knee will be defined as ROA worsening if its K/L grade increased by at least 1 grade except for the change from 0 to 1 during follow-up. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The Western Ontario and McMaster Universities Osteoarthritis Index | 3 years after enrollment | The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) will be assessed at baseline and in 3 years, from which symptoms of patients can be estimated. |
Contacts
Primary ContactChutong Lin
Outcome results
None listed