Infertility, Polycystic Ovarian Syndrome
Conditions
Keywords
LOD, PCOS, AMH, OHSS
Brief summary
To evaluate the effect of performing laparoscopic ovarian drilling (LOD) before proceeding to in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) on the cycle outcomes in polycystic ovarian syndrome (PCOS) patients with high antimullerian hormone (AMH) levels
Detailed description
Retrospective case-control study of PCOS women with high serum AMH level (≥ 7 ng/ml) who were subjected IVF/ICSI. Women underwent LOD in the preceding 3 months prior to IVF/ICSI (study group) will be compared with a control group of women who did not underwent LOD (control group)
Interventions
PROCEDURELOD
Women underwent LOD in the preceding 3 months prior to IVF/ICSI
Sponsors
Mansoura University
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* PCOS women subjected to COS through fixed gonadotropin releasing hormone (GnRH) antagonist protocol with final triggering of oocyte maturation by GnRH agonist (GnRHa) * Elevated serum AMH level (≥ 7 ng/ml)
Exclusion criteria
* Age \< 18 years or \> 35 years * Body mass index (BMI) \< 19 kg/m2 or \> 35 kg/m2 * Use of cabergoline therapy or coasting to minimize the risk of OHSS
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of oocytes retrieved | 36-38 hours after triggering of oocyte maturation | Number of collected oocytes during oocyte retrieval |
| Oocyte maturity rate | Within one hour after oocyte retrieval | Calculated for each woman by dividing the number of mature oocytes (MII oocytes) by the total number of oocytes retrieved |
| Fertilization rate | 20-24 hours after injection (or insemination) | Calculated for each couple by dividing the number of fertilized oocytes by the number of injected (or inseminated) oocytes |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical pregnancy rate | 6 weeks after embryo transfer | Number of clinical pregnancies (defined as presence of at least one intrauterine gestational sac with fetal pole and cardiac activity on TVS scan at 4-6 weeks after the ET) divided by the number of ET procedures |
| Implantation rate | 6 weeks after embryo transfer | Number of gestational sacs on TVS scan at 4-6 weeks after ET divided by the number of transferred embryos |
| Incidence of early OHSS | Within 9 days of final triggering of oocyte maturation | Incidence of OHSS within 9 days of final triggering of oocyte maturation |
Countries
Egypt
Outcome results
None listed