Closed-loop Anaesthesia for Liver Transplantation: a Pilot Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03357900

Acronym

THConcentr

Enrollment

Registered

2017-11-30

Start date

2010-08-18

Completion date

2012-02-09

Last updated

2017-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia, Liver Transplant

Keywords

Consciousness Monitor, Clinical Pharmacology

Brief summary

Automated titration of propofol and remifentanil guided by the bispectral index (BIS) has been used for numerous surgical procedures. Orthotopic liver transplantation (OLT) uniquely combines major volaemic changes, an anhepatic phase, and ischaemia-reperfusion syndrome. We assessed the behaviour of this automated controller during OLT

Interventions

DEVICEAutomated titration of propofol and remifentanil

Calculation of Consumption of propofol and remifentanil

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Patients scheduled for OLT

Exclusion criteria

age younger than 18 years, pregnancy, allergy or hypersensitivity to propofol or remifentanil, a medical history of psychiatric illness, and supraspinal neurological disorders

Design outcomes

Primary

Measure	Time frame
percentage of time spent in the BIS interval [40-60]	1 day

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026