Correlation of Two Methods for Cough Peak Flow Measurement in Intubated Patients

Correlation of Cough Peak Flow Measurement by an Electronic Handheld Spirometer Connected to the Endotracheal Tube and by the Intensive Care Unit Ventilator Flowmeter.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03357198

Acronym

COUGH-ICU

Enrollment

Registered

2017-11-29

Start date

2017-12-08

Completion date

2018-08-29

Last updated

2019-01-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Insufficiency, Ventilator Weaning

Brief summary

Cough Peak Flow (CPF) seems to be an efficient tool to assess cough capacity for the intensive care unit (ICU) ventilated patient. CPF can be used in the ventilator weaning process, as reflecting the upper airways protection capacity. CPF requires disconnection of the patient from the ICU ventilator, supplemental material (handheld spirometer, antibacterial filter) and an excellent synchronization between the specialized caregiver and the patient. We aimed that CPF with the ventilator built-in flow-meter is correlated with CPF using a handheld flowmeter connected to the endotracheal tube.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age \> 18 years * Mechanically ventilated patient \> 24 hours * Weaning ventilator phase (PEEP \< 9 cmH2O and Support \< 15 cm H2O) * Richmond Agitation Sedation Scale between -1 and +1 * Patient's agreement to participate

Exclusion criteria

* Pregnant women * Bronchospasm * FiO2 \> 70% * Thoracic surgery \< 7 days * Abdominal surgery \< 7 days * Thoracic injury with rib fracture \< 21 days * Pneumothorax \< 24 hours

Design outcomes

Primary

Measure	Time frame	Description
Correlation coefficient for the two CPF assessment methods, on extubation day	Within 1 hour before mechanical ventilation termination (extubation)	Correlation coefficient for the two CPF assessment methods, on extubation day

Secondary

Measure	Time frame	Description
Discriminatory power of CPF to predict successful weaning of mechanical ventilation, i.e. no reintubation within 72 hours after extubation, or unsuccessful weaning.	During the mechanical ventilation until 72 hours post extubation	Thresholds of CPF will be tested as predictors of weaning success
Assess the correlation between CPF and length of mechanical ventilation	During the mechanical ventilation until 72 hours post extubation	Assess the correlation between CPF and length of mechanical ventilation
3. Correlation between the two CPF assessment methods the days before extubation	During the mechanical ventilation until 72 hours post extubation	3\. Correlation between the two CPF assessment methods the days before extubation

Countries

France

Outcome results