Alveolar Bone Atrophy, Bone Resorption
Conditions
Brief summary
This study evaluates the effect of citric acid demineralization in autogenous bone blocks consolidation. Half of participants will receive citric acid treatment at the bone block and recipient site. Other half will receive no demineralization treatment.
Detailed description
Autogenous bone grafts are indicated in areas where there is not enough bone height and/or width for implant installation. Treatment of bone surfaces with citric acid, promote a slight demineralization on surface that mimic natural processes of bone demineralization by osteoclasts. Thus, this treatment could accelerate the process of autogenous bone block consolidation to its recipient site.
Interventions
PROCEDUREControl
Control side will receive only perforations on recipient site, which is the conventional technique for bone blocks graft.
PROCEDUREAcid
Test side will receive treatment with citric acid (10%) for 30s at bone block surface and recipient site
Sponsors
University of Sao Paulo
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Intervention model description
Split mouth design - one side of mouth is test group, other side is control group
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Presence of atrophic anterior maxilla (width 1.5 to 4 mm) * Absence of active periodontal disease. * Enough bone width on donor sites (oblique line or ment)
Exclusion criteria
* Systemic disease that impede surgical procedure as blood diseases, endocrine diseases, impaired coagulation * Smokers * Pregnant women * Patients receiving radiotherapy or chemotherapy * Patients using bisphosphonates
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical bone block consolidation | 5 months | Absence of fibrous tissue by clinical observation |
| Computerized tomography images bone block consolidation | 5 months | Absence of images compatible to fibrosis in cone beam computerized tomography images |
| Histological bone block consolidation | 5 months | Absence of fibrous tissue between bone block and recipient site in histological images. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Bone width | 5 months | Measurement of bone width in mm on cone beam computerized tomography. Ideal if \>6 mm. |
Countries
Brazil
Outcome results
None listed