Glucose Intolerance, Insulin Resistance, Oxidative Stress, Vitamin D Deficiency
Conditions
Brief summary
The investigators aim to determine the effect of the correction of vitamin D in vitamin D deficient patients (\<15ng/ml) in oxidative stress and insulin resistance in patients with impaired glucose tolerance. Vitamin D deficiency has been associated with chronic low-grade inflammation, diabetes mellitus type 2, cardiovascular risk and increased prevalence of coronary heart disease, cerebrovascular disease and myocardial infarction.
Interventions
DRUGVitamin D
Vitamin D supplementation
OTHERPlacebo
Placebo
Sponsors
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Women, 18 to 70 years, glucose intolerance (post-2 hour 75-grams glucose load \> or equal 140 mg/dl), 25-hydroxy vitamin D concentration \< or equal 15 ng/ml
Exclusion criteria
* Diabetes, systemic inflammatory disorders, treatment with statins, metformin or fibrates, renal insufficiency, intestinal malabsorption
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in anti-oxidant capacity measured in serum | One month | Change in serum anti-oxidant capacity after one month |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in homeostasis model assessment (HOMA) index measured in serum | One month | Change in homeostasis model assessment (HOMA) index after one month |
Countries
Mexico
Outcome results
None listed