Lung Cancer
Conditions
Keywords
lobectomy
Brief summary
This study will analyze spectral features of the radiofrequency of lung tumors in ex-vivo human lungs. The resected specimens will be evaluated using the spectrum analysis to determine the localization rate of the targets. Ultrasound measurement and images will be used for correlation of TS mode image findings with pathology by using HE and IHC slides of lung tumor and lymph node.
Interventions
DEVICESpectrum Analysis
The ultrasound probe will be placed on the lung surface in several different directions to obtain the cross section with maximum diameter. Three spectral parameters including midband-fit (dB), intercept (dB), and slope (dB/MHz) will be calculated and compared between the tumor and the lung.
Sponsors
University Health Network, Toronto
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Any patients scheduled for lobectomy of anatomical segmental resection for malignant lung tumors. * 18 years of age or older
Exclusion criteria
* Any patients with inability to give informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To analyze the relationship of three spectral features of the radiofrequency of lung tumors in ex-vivo human lungs. | Within an hour after resection. | From obtained ultrasound images, a linear regression line is quantified, and three ultrasonic spectral parameters including Midband-fit, Intercept, and Slope are calculated. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| To find the correlation of TS mode image findings with pathology by using lung tumor and lymph node samples. | Within an hour after resection | After evaluation, the actual tumor size and histological diagnosis will be determined. Differences between US image and pathological morphology will be determined by using HE and Immunohistochemistry (IHC) slides of lung tumor, the investigators will evaluate comparison of nucleus size in each tissue and the spectral parameters in each region of interest. |
| To clarify the feasibility of using the conventional EBUS scope to visualize solitary pulmonary nodules in an ex-vivo human lung. | Within an hour after resection | The bronchial stump of the specimen will be opened and a small sized endotracheal tube will be inserted to inflate and deflate the lung. After inflation of the lung, visualization of the tumor will be evaluated to see the difference in ultrasound images between deflated and inflated lung. |
Countries
Canada
Outcome results
None listed