Stiffness, Aortic, Cardiac Remodeling, Ventricular, Vascular Remodeling, Magnetic Resonance Imaging, Functional, Athletes
Conditions
Keywords
Aortic compliance, Aortic distensibility, CMR, Triathletes, Ventriculo-atrial coupling
Brief summary
Regular sustained physical activity creates a cardiac remodelling : it is athlete's heart. In our preliminary work published in 2016, the investigators demonstrated in a small population of triathletes that there is also a vascular remodelling named athlete's artery. Moreover, the investigators know that left ventricle and aorta behave together like a couple. So they want to study by Cardiovascular Magnetic Resonance Imaging the impact of triathlon on the cardiac AND aortic remodelling.
Interventions
DEVICECardiac MRI
Non injected cardiac MRI exam
DEVICEApplanation tonometry
Applanation tonometry and ECG
Sponsors
Central Hospital, Nancy, France
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 39 Years
Healthy volunteers
Yes
Inclusion criteria
* to be enrolled in a social security plan. * to have a BMI between 18,5 and 25 kg/m² * to have received full information on the organization of the research and having signed its informed consent * to have carried out a clinical screening adapted to the research \*\*\* Triathlete group: * to have a minimum performance level: between 2h and 2h45 on an M triathlon during the past year (provide proof), * to participate in 2018 in a long distance triathlon, i. e. at least distance L * to have a defined training volume: less than 8 hours per week during the winter months and between 10 and 15 hours per week in preparation of the objective \*\*\*Control group: * to have no more than 150 minutes of moderate physical activity per week (footing, brisk walking, cycling, etc.).
Exclusion criteria
* Persons referred to in Articles L. 1121-5 to L. 1121-8 and L1122-2 of the Public Health Code * Cardiovascular history including Ii.e. known heart rhythm disorders * Chronic disease: diabetes, high blood pressure... * Long-term drug therapies that may modify cardiovascular remodeling such as Conversion Enzyme Inhibitor, Angiotensin II Receptor Antagonist, * Active smoking, even if occasional * Contraindication to MRI
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Aortic compliance in triathletes in mm2/mmHG | at baseline, at the fitness peak (6 to 10 months later) and at recovery (3 to 6 months after the fitness peak) | aortic compliance = pulsed pressure-to-absolute variation of aortic surface ratio |
Countries
France
Outcome results
None listed