Adenoma Detection Rate, Bowel Preparation Scale
Conditions
Keywords
Polyp detection rate, Adenoma detection rate, Boston Bowel Preparation Scale
Brief summary
High quality bowel preparation is essential for successful colonoscopy. This study aimed to assess the impact of the dose of Polyethylene Glycol(PEG) on the quality of bowel preparation. This prospective, endoscopist-blinded, randomized, controlled study was conducted. 3L-group received 3 bags of PEG and were instructed to drink 1L at 19:00 in the evening before the day of colonoscopy at a rate of 250 mL every 15 minutes, and to drink the remaining 2L 4 to 6 h before colonoscopy at the same rate. 4L-group received 4bags of PEG and were instructed to drink 2 L at 19:00 in the evening before the day of colonoscopy at a rate of 250 mL every 15 minutes, and to drink the remaining 2L 4 to 6 h before colonoscopy at the same rate. The primary outcome was the quality of the bowel preparation according to the Boston Bowel Preparation Scale (BBPS). The secondary outcomes included polyp detection rate (PDR), adenoma detection rate (ADR), tolerance, and subjective feelings of patients.
Interventions
DRUG4L Polyethylene Glycol
4L group received double-dose PEG at 19:00 in the evening before the day of colonoscopy at a rate of 250 mL every 15 minutes.
DRUG3L Polyethylene Glycol
3L group were instructed to drink 1L PEG at 19:00 in the evening before the day of colonoscopy at a rate of 250 mL every 15 minutes
Sponsors
Changhai Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
1. Outpatients aged 18-75 years 2. Referred for routine diagnostic colonoscopy 3. Patients who have signed inform consent form
Exclusion criteria
1. pregnancy or breastfeeding 2. allergy to purgatives 3. suspected intestinal obstruction, stricture, or perforation 4. hemodynamic instability 5. impaired swallowing reflex or mental status 6. severely medical status, such as New York Heart Association grade III or grade IV congestive heart failure and severe renal failure 7. history of oesophagus、stomach 、duodenum、small intestine or colorectal surgery 8. participation declined.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the Boston Bowel Preparation Scale | 2 days | The primary end point of the study was adequate bowel preparation quality de ned as a BBPS total score of ≥6 with all segment scores ≥2 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Polyp detection rate | 2 days | The secondary end point of the study included polyp detection rate |
| Adenoma detection rate | 2 days | The secondary end point of the study included adenoma detection rate |
| The mean number of incremental adenomas | 2 days | It was a new metric called ADR-Plus, the mean number of incremental adenomas after the fist. |
Countries
China
Contacts
Primary ContactZhaosheng Li, MD
Backup ContactYu Bai, MD
Outcome results
None listed