Obesity, Metabolically Benign
Conditions
Keywords
adipokines, metabolic syndrome, obese children
Brief summary
Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C reactive protein (CRP) play an important role. This study aimed to investigate the relationship between markers of adiposity like leptin, adiponectin and high sensitive C reactive protein (hsCRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome in pediatric population
Detailed description
The idea that adipose tissue is just a form of energy storage has changed dramatically in recent years. Currently, adipose tissue is considered to be a true endocrine gland that fulfills multiple roles in regulating different biological functions. Communication between adipose tissue and the rest of the systems is accomplished through bioactive mediators (adipokines) Adipokines control energy homeostasis and are involved in metabolic, endocrine and immunological processes.This study aimed to investigate the relationship between markers of adiposity like leptin, adiponectin and high sensitive C reactive protein (hsCRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome in pediatric population.The current retrospective observational study was conducted at the Louis Turcanu Emergency Hospital Timisoara over a period of one year, from July 2013 and June 2014. All inborn patient files were analyzed as anonymised limited data sets from archived records of the Endocrinology, Diabetology and Cardiology department.
Interventions
Sponsors
University of Medicine and Pharmacy Victor Babes Timisoara
Alexandru Florin Rogobete
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
4 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* obese children (BMI\> 95th percentile)
Exclusion criteria
* obesity caused by endocrine disease, syndromic obesity, systemic disease or acute illness.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Defining obesity in the pediatric population | Weight and height were measured on day 1 of admission. Obesity was defined as a BMI > the 95th percentile. | Measuring weight in kilograms and height in meters in order to calculate BMI and represent it on the percentile graph. |
| Leptin changes in the obese children with metabolic syndrome | Leptin levels were measured on day 1 of admission. Normal range was considered < 24ng/ml. | Evaluating leptin in the obese group with metabolic syndrome |
| Adiponectin changes in the obese children with metabolic syndrome | Adiponectin levels were measured on day 1 of admittance in children aged between 4 and18 years. Levels 4-26 mcg/ml were defined as normal values. | Evaluating adiponectin in the obese group with metabolic syndrome |
| Assessing cardiovascular risk in the obese children with metabolic syndrome | hsCRP levels were measured on day 1 of admittance in children aged between 4 and 18 years. Normal levels were considered between 0.1-2.8 mg/l | Evaluating hsCRP in the obese group with metabolic syndrome |
Outcome results
None listed