Acute Kidney Injury, Acute Renal Failure, Hospital Acquired Condition, Kidney Failure, Acute
Conditions
Keywords
Acute Kidney Injury, Hospital-acquired Acute Kidney Injury, Community-acquired Acute Kidney Injury, Acute Renal Failure
Brief summary
This retrospective cohort study aims to investigate the incidence, risk factors and outcomes of Hospital-acquired Acute Kidney Injury in Hospital Selayang, a tertiary hospital at Malaysia, over 15 years.
Detailed description
This is a retrospective cohort study involving 5-yearly trend from 2002 to 2017 for analysis. Laboratory serum creatinine (SCr) results of all patients admitted during study period will be retrieved from the hospital Laboratory Information System. A preliminary screening list will be generated by using STATA program from the SCr results. The nephrologist will then determine HA-AKI and CA-AKI as per inclusion and exclusion criteria. Data collectors will collect all relevant data from these patients.
Interventions
OTHERNo AKI
Subjects will be allocated into this group if they did not acquire Acute Kidney Injury during admission.
OTHERCA-AKI
CA-AKI is defined by any patient who developed AKI (as per definition below) within 48 hours of hospital admission. Definition of AKI: i. An increase in serum creatinine of 0.3 mg/dl (26.5 μmol/l) within 48 hours OR ii. An increase in serum creatinine to more or equal to 1.5 times baseline, which is known or presumed to have occurred within the prior 7 days Definition for baseline creatinine: i. The baseline creatinine level is defined as the creatinine level at or within 7 days before the hospital admission, OR ii. at the hospital admission OR iii. the lowest creatinine (excluding the post dialysis creatinine if dialysis is initiated) during the index hospitalisation for those whose baseline creatinine were unknown.
OTHERHA-AKI
HA-AKI is defined by any patient who developed AKI (as per definition below) after 48 hours of hospital admission. Definition of AKI: i. An increase in serum creatinine of 0.3 mg/dl (26.5 μmol/l) within 48 hours OR ii. An increase in serum creatinine to more or equal to 1.5 times baseline, which is known or presumed to have occurred within the prior 7 days Definition for baseline creatinine: i. The baseline creatinine level is defined as the creatinine level at or within 7 days before the hospital admission, OR ii. at the hospital admission OR iii. the lowest creatinine (excluding the post dialysis creatinine if dialysis is initiated) during the index hospitalisation for those whose baseline creatinine were unknown.
Sponsors
Selayang Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult admissions to Hospital Selayang from * 1st July 2001 to 30th June 2002 * 1st July 2006 to 30th June 2007 * 1st July 2011 to 30th June 2012 * 1st July 2016 to 30th June 2017
Exclusion criteria
* End Stage Renal Failure and on Renal Replacement Therapy (Hemodialysis, peritoneal dialysis or Renal Transplant)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of Hospital-acquired Acute Kidney Injury | During admissions to study site (Year 2001-2002, Year 2006-2007, Year 2011-2012, Year 2016-2017) | Incidence of Hospital-acquired Acute Kidney Injury among the adult admissions |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Renal Recovery from Hospital-acquired Acute Kidney Injury | 90 days after diagnosis of Acute Kidney Injury | Renal Recovery among adult admissions for Hospital-acquired Acute Kidney Injury |
| In-hospital Mortality from Hospital-acquired Acute Kidney Injury | During admissions to study site with Hospital-acquired Acute Kidney Injury, through study completion (an average of 1 year) | Mortality rate among adult admissions for Hospital-acquired Acute Kidney Injury |
Countries
Malaysia
Outcome results
None listed