Bipolar Disorder, Cognitive Symptom
Conditions
Keywords
neurocognition, prognosis, aerobic exercise
Brief summary
This study will investigate the effects of aerobic exercise on mental states, cognition, BDNF, and long-term outcomes in patients with bipolar disorder.
Detailed description
Multiple cognitive impairments are common in patients with bipolar disorder. Preliminary evidence shows that aerobic exercise might have positive effects in enhancing cognition and improving clinical symptoms in patients with mood disorders. This randomized controlled trial will investigate short-term (1 months) effects of aerobic exercise on cognition and clinical symptoms as well as the long-term (12 months) effects on decreasing the recurrence rate.
Interventions
BEHAVIORALaerobic exercise
Cycling at the intensity of 50%-70% of maximum heart rate (220-age) for 30 mins per day, 4 days per week, last for 1 months.
BEHAVIORALPlacebo controlled group
General intensity activities of recreation therapy, including Handicraft manufacture, reading activity, singing entertainment, walking.
Sponsors
Guangzhou Psychiatric Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* DSM-IV defined bipolar disorder. * Never accept aerobic exercise therapy. * dextromanuality.
Exclusion criteria
* Diagnosed neurological or musculoskeletal disorder/injury, * Uncontrolled cardiovascular or metabolic diseases that are not suitable for running * Diagnosed hypertension * Other diagnosed serious medical conditions that are not suitable for cycling * Severe suicidal ideation * Mental retardation * Currently participating in a exercise program or activity, defined as 30 minutes of vigorous physical activity 4-5 times per week
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in neurocognitive function | 12 months | Changes in neurocognitive function measured by the MATRICS Consensus Cognitive Battery (MCCB) after three months (12 weeks) of aerobic exercise |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| relapse rate | 12 months | Relapses of depressive and/or hypo/manic episodes |
| depressive symptoms | 4 weeks, 4 months, 12 months | depressive symptoms measured by Hamilton Depression Scale |
| manic symptom | 4 weeks, 4 months, 12 months | manic symptom measured by Young Manic Rating Scale |
Countries
China
Contacts
Primary ContactKangguang Lin, MD, PhD
Backup ContactYaoguang Guo, MPH
Outcome results
None listed