Cardiovascular Risk Markers in Spinal Cord Injured Subjects of the Wheelchair Dancer Study

Associations Between the Cardiovascular Risk Markers and Neuroplasticity in Sedentary or Physically Active Spinal Cord Injured Subjects of the Wheelchair Dancer Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03352505

Enrollment

Registered

2017-11-24

Start date

2017-10-01

Completion date

2021-01-28

Last updated

2021-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Risk Factor, SCI - Spinal Cord Injury

Brief summary

The present study will analyze if exercise is able to elicit the well-known anti-atherogenic effects in patients with SCI. This will be evaluated by measuring vascular parameters such as endothelial and inflammatory blood markers, echocardiography of the heart and peripheral vessels, as well as blood pressure and arterial stiffness, in subjects performing either wheelchair dancing, wheelchair marathon or no sports. Further, it will be investigated, whether there is an association between neuroplasticity and cardiovascular health, as measured by electroencephalography (EEG), transcranial magnetic stimulation (TMS) and blood levels of the brain-derived neurotrophic factor (BDNF). We hypothesize that the cardiovascular, physical and psychological benefits of wheelchair dancing and/or wheelchair marathon parallel improved neuroplasticity in SCI-patients

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

wheelchair users independent of the cause of the walking impairment, preferably with spinal cord injury.

Exclusion criteria

metallic implanters, additional neurologic pathologies, pregnancy

Design outcomes

Primary

Measure	Time frame	Description
comparison of cardiovascular risk factors between different study groups	October 2017- June 2018	measurement for arterial stiffness parameters, via pulse wave analysis. Comparison between healthy individuals and patients using wheelchairs (three different groups).
Evaluation of echocardiography results between different study groups	October 2017- June 2018	Evaluation of echocardiography comparing healthy individuals and patients using wheelchairs (three different groups).

Countries

Austria

Outcome results