Creatine Supplementation, Healthy
Conditions
Brief summary
To assess whether brain creatine availability has an effect on cognition. To do so we will seek to increase brain creatine concentration via a creatine supplementation protocol.
Interventions
DIETARY_SUPPLEMENTCreatine
Participants will have to supplement themselves with creatine for 7 days (20g/day).
DIETARY_SUPPLEMENTCalcium lactate
Participants will have to supplement themselves with calcium lactate for 7 days (elemental calcium: 0.780g/day).
Sponsors
Vrije Universiteit Brussel
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy (No neurological illness including cardiovascular, renal, and endocrine disorder) * Male/female * No medication / supplements * Non-smoker * Low to moderately active * Between 18 and 35 years old
Exclusion criteria
* Injuries * Illness * Use of medication * Use of creatine in the last 3 months * History of head trauma or seizure * Vegetarian diet \[24\] * Not being able to follow up the restrictions and prohibitions for the subjects (see Restrictions and prohibitions for the subjects)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive performance - change in accuracy (%) during a 90-min cognitive task (i.e. Stroop task) | During both lab visits (i.e. after both 7-day supplementation protocols); Accuracy (%) will be assessed during both lab visits with a 90-min cognitive task; Accuracy during the 90-min task will be reported as mean accuracy during 8 blocks of 11min15sec | Accuracy (in %) will be assessed during a cognitive task, this cognitive task will be completed after both 7-day supplementation protocols (i.e. placebo and creatine) |
| Cognitive performance - change in reaction time (milliseconds) during a 90-min cognitive task (i.e. Stroop task) | During both lab visits (i.e. after both 7-day supplementation protocols); Reaction time (RT) will be assessed during both lab visits with a 90-min cognitive task; RT during the 90-min task will be reported as mean RT during 8 blocks of 11min15sec | Reaction time (in milliseconds) will be assessed during a cognitive task, this cognitive task will be completed after both 7-day supplementation protocols (i.e. placebo and creatine) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Physical performance - reaction time (milliseconds) during a 7-min visuomotor reaction time task | During both lab visits (i.e. after both 7-day supplementation protocols); visuomotor reaction time will be assessed during both lab visits with a 7-min visuomotor reaction time task. | Reaction time (in milliseconds) will be assessed during a visuomotor reaction time task, this physical task will be completed after both 7-day supplementation protocols (i.e. placebo and creatine) |
Countries
Belgium
Outcome results
None listed