Atherosclerosis, Metabolic Syndrome
Conditions
Brief summary
Prolonged sitting has been shown to effect the response to a high fat tolerance test (HFTT) after acute exercise. This study will evaluate the effect of prolonged sitting on response to a HFTT after a short term training period.
Interventions
BEHAVIORALProlonged sitting with exercise
Subjects will commit to sitting more than 11 hours per day and taking less than 5000 steps per day while participating in exercise training.
BEHAVIORALActive walking with exercise.
Subjects will commit to sitting less than 5 hours per day and taking more than 10000 steps per day while participating in exercise training.
Sponsors
University of Texas at Austin
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
Subjects will be randomly assigned to either the sitting plus exercise or walking plus exercise.
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* 18 to 35 years
Exclusion criteria
* cardiovascular problems (e.g. pre-existing heart issues, coronary artery disease, hypertension, etc.) * respiratory problems * musculoskeletal problems that prevent prolonged sitting or exercise * obesity * susceptibility to fainting * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Plasma Triglycerides | 6 hours | Areas under the curve for triglyceride concentration will be calculated for hourly samples from a 6-hour lipid tolerance test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Plasma Insulin | 6 hours | Areas under the curve for insulin concentration will be calculated for hourly samples from a 6-hour lipid tolerance test |
| Plasma glucose | 6 hours | Areas under the curve for glucose concentration will be calculated for hourly samples from a 6-hour lipid tolerance test |
Countries
United States
Outcome results
None listed