Acute Myocardial Infarction, Heart Failure With Preserved Ejection Fraction, Predictor, Prognosis
Conditions
Keywords
Heart Failure with Preserved Ejection Fraction, Acute MyocAcute Myocardial Infarction, Predictive factors
Brief summary
This retrospective observation is to investigate the incidence,clinical outcomes and prognosis of hospitalized heart failure with preserved ejection fraction (HFpEF) in patients with acute myocardial infarction(AMI).
Detailed description
1. Patients with first AMI undergoing primary percutaneous coronary intervention (PCI) in our hospital since January 2013 were retrospectively evaluated. The enrolled subjects were divided into two groups (AMI patients with HFpEF and AMI patients without HF). 2. The investigator collected the clinical data of participants' demographics (age, sex), previous history,risk factors for AMI (hypertension, hyperlipidemia, diabetes mellitus, smoking and stroke), laboratory biomarkers, echocardiographic measurements, clinical characteristics,medical procedures and treatments, as well as in-hospital complications. 3. Two sub-investigators independently analyzed these data by using SPSS software.
Interventions
COMBINATION_PRODUCTclinical characteristics, previous history, laboratory bio-markers, echocardiographic measurements, angiographic findings,clinical outcomes
The differences of data(clinical characteristics, history, laboratory biomarkers, echocardiographic measurements, angiographic characteristics and clinical outcomes) in two groups were conducted. The differences between two groups were compared (clinical characteristics, history, laboratory biomarkers, echocardiographic measurements, angiographic characteristics and clinical outcomes) in two groups were compared, and then found the risk factors. Following,the incidence of clinical outcomes and mortality were compared. Then, univariate logistic regression and multivariate logistic regression analysis adjusted for significant risk factors were performed to find out the independent predictive factors. Finally, the ROC was constructed, and the area was evaluated to assess the predicted probability of regression model.
Sponsors
Xiangjun Yang
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* First AMI patients undergoing PCI with HFpEF or without HF.
Exclusion criteria
* First AMI patients with heart failure with reduced ejection fraction. * First AMI patients with severe inflammatory diseases, valvular heart disease, non-cardiac caused symptoms, serious hepatic and renal failure, congenital cardiomyopathy,or pericardial diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Risk factors of incident in-hospital HFpEF | Outcome measure will be assessed at discharge, and data will be reported through study completion, an average of 1 year. |
Secondary
| Measure | Time frame |
|---|---|
| Clinical prognosis in patients with HFpEF | Outcome measure will be assessed at discharge, and data will be reported through study completion, an average of 1 year. |
Countries
China
Outcome results
None listed