Pain After PRP Revascularization and Endodontic Treatment of Non-vital Mandibular Molars With Apical Periodontitis

Evaluation of Post-operative Pain Following Platelet Rich Plasma (PRP) Revascularization Versus Conventional Endodontic Treatment of Non-vital Mature Mandibular Molars With Chronic Peri-apical Periodontitis

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03350841

Enrollment

Registered

2017-11-22

Start date

2018-01-31

Completion date

2019-12-31

Last updated

2017-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Pain

Brief summary

randomized clinical trial which Evaluate thr Post-operative Pain Following Platelet Rich Plasma (PRP) Revascularization versus Conventional Endodontic Treatment of Non-vital Mature Mandibular Molars with Chronic Peri-apical Periodontitis

Detailed description

it will be done in 2 visits where in the firist visit, i will finish cleaning and shaping of the canals and inject double antibiotic paste as intracanal medication. in the second visit, removal of intracanal medication then obturaton of the canals in the control group. while in the intervention group,over instrumentation of the canals beyond the working length using k-file size 20-35 to establish bleeding in the canals.then blood sample is collected for PRP preparation then injected into the canal.the patient will record post operative pain 6,12,24,48 hours then 3,4,5 days later.then they will do CBCT at 6, 12 months after the treatment to assess peri-apical healing

Interventions

PROCEDUREPlatelet rich plasma PRP

blood sample is collected to prepare platelet rich plasma injected in the canal

PROCEDUREroot canal treatment

conventional root canal treatment and obturation with guttapercha

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

15 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Medically free patients, between 18-40 years * Patients with necrotic pulp in mandibular molar permanent teeth with closed apex

Exclusion criteria

* Illiterate patient * Patients with systemic diseases * Pregnant women * Patients that have allergy to ciprofloxacin or metronidazole * Teeth that: * Have vertical root fracture, coronal perforation, and calcification. * re-treatment cases * Non restorable * Patients that have T.M.J. disorder

Design outcomes

Primary

Measure	Time frame	Description
Post-operative Pain	5 days	postoperative pain evaluated using NRS scale It is a numerical rating scale from 0-10 with 0 representing no pain and 10 representing worst pain

Secondary

Measure	Time frame	Description
healing	12 months	healing of periapical tissue evaluated radiographically

Countries

Egypt

Contacts

Primary Contactyassmin ahmed

yassmin.ahmed@dentistry.cu.edu.eg00201006088594

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 12, 2026